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- W2043288848 endingPage "67" @default.
- W2043288848 startingPage "57" @default.
- W2043288848 abstract "Chronic airway inflammation is a common symptom of several diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Excessive or inappropriate immune system activity and/or failure to resolve an acute inflammation spontaneously can induce functional changes in the walls and parenchyma of the airways. Continuous recruitment of inflammatory cells to the site of inflammation and the production of protein (i.e., cytokines, chemokines, enzymes, etc.) and lipid (eicosanoids) pro-inflammatory mediators contribute directly or indirectly to changes in airway structure and function. Pro-inflammatory eicosanoids are mainly formed by the metabolism of arachidonic acid, an n-6 polyunsaturated fatty acid esterified at the s-n2 position of membrane phospholipids. Unlike n-6 polyunsaturated fatty acids (PUFA), n-3 PUFA decrease inflammation. The anti-inflammatory effect of n-3 PUFA derives from their ability to compete with arachidonic acid in the production of eicosanoids, thereby decreasing the production of pro-inflammatory cytokines and reducing immune cell functions. Moreover, n-3 PUFA can give rise to a series of pro-resolving mediators with anti-inflammatory actions, such as resolvins and protectins. While most studies have reported n-3 PUFA to have beneficial effects on chronic airway diseases, some have questioned the anti-inflammatory effects of n-3 PUFA in inflammatory airway diseases. This paper summarizes the main mechanisms by which n-3 PUFA exert anti-inflammatory and pro-resolving effects, focusing on their use in airway disorders with an inflammatory component." @default.
- W2043288848 created "2016-06-24" @default.
- W2043288848 creator A5021863511 @default.
- W2043288848 creator A5059219187 @default.
- W2043288848 date "2012-12-01" @default.
- W2043288848 modified "2023-10-17" @default.
- W2043288848 title "Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases" @default.
- W2043288848 cites W1497700962 @default.
- W2043288848 cites W1502595840 @default.
- W2043288848 cites W1512762418 @default.
- W2043288848 cites W1538565107 @default.
- W2043288848 cites W1555290161 @default.
- W2043288848 cites W1689352214 @default.
- W2043288848 cites W169134854 @default.
- W2043288848 cites W1911441831 @default.
- W2043288848 cites W1926255205 @default.
- W2043288848 cites W1964899513 @default.
- W2043288848 cites W1966886936 @default.
- W2043288848 cites W1970148313 @default.
- W2043288848 cites W1971662522 @default.
- W2043288848 cites W1974020732 @default.
- W2043288848 cites W1974946679 @default.
- W2043288848 cites W1975419167 @default.
- W2043288848 cites W1975959231 @default.
- W2043288848 cites W1976355797 @default.
- W2043288848 cites W1977947625 @default.
- W2043288848 cites W1984160742 @default.
- W2043288848 cites W1984916101 @default.
- W2043288848 cites W1986356926 @default.
- W2043288848 cites W1988367310 @default.
- W2043288848 cites W1992710087 @default.
- W2043288848 cites W1993279018 @default.
- W2043288848 cites W1994622879 @default.
- W2043288848 cites W1994965038 @default.
- W2043288848 cites W1995017236 @default.
- W2043288848 cites W1995525413 @default.
- W2043288848 cites W1995777086 @default.
- W2043288848 cites W1997119259 @default.
- W2043288848 cites W1997905300 @default.
- W2043288848 cites W2003095334 @default.
- W2043288848 cites W2003251689 @default.
- W2043288848 cites W2009922820 @default.
- W2043288848 cites W2010208657 @default.
- W2043288848 cites W2010233335 @default.
- W2043288848 cites W2011458650 @default.
- W2043288848 cites W2013268035 @default.
- W2043288848 cites W2016008825 @default.
- W2043288848 cites W2017340159 @default.
- W2043288848 cites W2023690878 @default.
- W2043288848 cites W2028595448 @default.
- W2043288848 cites W2030856838 @default.
- W2043288848 cites W2036196585 @default.
- W2043288848 cites W2038557613 @default.
- W2043288848 cites W2039608694 @default.
- W2043288848 cites W2041407803 @default.
- W2043288848 cites W2041765490 @default.
- W2043288848 cites W2041831203 @default.
- W2043288848 cites W2047629476 @default.
- W2043288848 cites W2049258436 @default.
- W2043288848 cites W2050747371 @default.
- W2043288848 cites W2051637330 @default.
- W2043288848 cites W2052328166 @default.
- W2043288848 cites W2056294485 @default.
- W2043288848 cites W2057877030 @default.
- W2043288848 cites W2059751934 @default.
- W2043288848 cites W2061265013 @default.
- W2043288848 cites W2069147283 @default.
- W2043288848 cites W2071755982 @default.
- W2043288848 cites W2073079404 @default.
- W2043288848 cites W2073878918 @default.
- W2043288848 cites W2074130482 @default.
- W2043288848 cites W2074277275 @default.
- W2043288848 cites W2076111774 @default.
- W2043288848 cites W2076974145 @default.
- W2043288848 cites W2077180157 @default.
- W2043288848 cites W2078759697 @default.
- W2043288848 cites W2080774711 @default.
- W2043288848 cites W2083666530 @default.
- W2043288848 cites W2085296733 @default.
- W2043288848 cites W2087304709 @default.
- W2043288848 cites W2088052697 @default.
- W2043288848 cites W2089881178 @default.
- W2043288848 cites W2090807187 @default.
- W2043288848 cites W2094100039 @default.
- W2043288848 cites W2096340924 @default.
- W2043288848 cites W2102410401 @default.
- W2043288848 cites W2102502619 @default.
- W2043288848 cites W2102545533 @default.
- W2043288848 cites W2102684777 @default.
- W2043288848 cites W2102997995 @default.
- W2043288848 cites W2103010344 @default.
- W2043288848 cites W2106538804 @default.
- W2043288848 cites W2109225320 @default.
- W2043288848 cites W2111253176 @default.
- W2043288848 cites W2111702908 @default.
- W2043288848 cites W2112482109 @default.
- W2043288848 cites W2113274857 @default.
- W2043288848 cites W2114637517 @default.