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- W2043291671 abstract "The mammalian intestine encounters many more microorganisms than any other tissue in the body thus making it the largest and most complex component of the immune system. Indeed, there are greater than 100 trillion (1014) microbes within the healthy human intestine, and the total number of genes derived from this diverse microbiome exceeds that of the entire human genome by at least 100-fold. Our coexistence with the gut microbiota represents a dynamic and mutually beneficial relationship that is thought to be a major determinant of health and disease. Because of the potential for intestinal microorganisms to induce local and/or systemic inflammation, the intestinal immune system has developed a number of immune mechanisms to protect the host from pathogenic infections while limiting the inflammatory tissue injury that accompanies these immune responses. Failure to properly regulate intestinal mucosal immunity is thought to be responsible for the inflammatory tissue injury observed in the inflammatory bowel diseases (IBD; Crohn disease, ulcerative colitis). An accumulating body of experimental and clinical evidence strongly suggests that IBD results from a dysregulated immune response to components of the normal gut flora in genetically susceptible individuals. The objective of this review is to present our current understanding of the role that enteric microbiota play in intestinal homeostasis and pathogenesis of chronic intestinal inflammation." @default.
- W2043291671 created "2016-06-24" @default.
- W2043291671 creator A5014512255 @default.
- W2043291671 creator A5052499467 @default.
- W2043291671 creator A5061742377 @default.
- W2043291671 creator A5076390595 @default.
- W2043291671 date "2014-03-01" @default.
- W2043291671 modified "2023-10-10" @default.
- W2043291671 title "Role of the enteric microbiota in intestinal homeostasis and inflammation" @default.
- W2043291671 cites W1552685796 @default.
- W2043291671 cites W1579108180 @default.
- W2043291671 cites W1809561724 @default.
- W2043291671 cites W1845975704 @default.
- W2043291671 cites W1967217097 @default.
- W2043291671 cites W1977761329 @default.
- W2043291671 cites W1980914602 @default.
- W2043291671 cites W1982229304 @default.
- W2043291671 cites W1987610510 @default.
- W2043291671 cites W1987907874 @default.
- W2043291671 cites W1989700624 @default.
- W2043291671 cites W1989995233 @default.
- W2043291671 cites W1990236675 @default.
- W2043291671 cites W1991072797 @default.
- W2043291671 cites W1991081070 @default.
- W2043291671 cites W1993399595 @default.
- W2043291671 cites W1993463781 @default.
- W2043291671 cites W1997484087 @default.
- W2043291671 cites W1997702183 @default.
- W2043291671 cites W2000208875 @default.
- W2043291671 cites W2001884635 @default.
- W2043291671 cites W2002061924 @default.
- W2043291671 cites W2003525072 @default.
- W2043291671 cites W2004608617 @default.
- W2043291671 cites W2008623255 @default.
- W2043291671 cites W2011297553 @default.
- W2043291671 cites W2011848880 @default.
- W2043291671 cites W2013482710 @default.
- W2043291671 cites W2019279852 @default.
- W2043291671 cites W2020913417 @default.
- W2043291671 cites W2025065287 @default.
- W2043291671 cites W2030857487 @default.
- W2043291671 cites W2031253671 @default.
- W2043291671 cites W2034048156 @default.
- W2043291671 cites W2034082915 @default.
- W2043291671 cites W2034598453 @default.
- W2043291671 cites W2034706392 @default.
- W2043291671 cites W2035831689 @default.
- W2043291671 cites W2036500213 @default.
- W2043291671 cites W2036629065 @default.
- W2043291671 cites W2037907937 @default.
- W2043291671 cites W2040512118 @default.
- W2043291671 cites W2042022899 @default.
- W2043291671 cites W2042245200 @default.
- W2043291671 cites W2047208232 @default.
- W2043291671 cites W2049085828 @default.
- W2043291671 cites W2049448291 @default.
- W2043291671 cites W2050849048 @default.
- W2043291671 cites W2053388673 @default.
- W2043291671 cites W2056386675 @default.
- W2043291671 cites W2058935348 @default.
- W2043291671 cites W2059005097 @default.
- W2043291671 cites W2059839808 @default.
- W2043291671 cites W2060185417 @default.
- W2043291671 cites W2060485250 @default.
- W2043291671 cites W2061275484 @default.
- W2043291671 cites W2068234766 @default.
- W2043291671 cites W2072254837 @default.
- W2043291671 cites W2072417345 @default.
- W2043291671 cites W2073795434 @default.
- W2043291671 cites W2074692187 @default.
- W2043291671 cites W2078599166 @default.
- W2043291671 cites W2082732215 @default.
- W2043291671 cites W2083759302 @default.
- W2043291671 cites W2084814249 @default.
- W2043291671 cites W2085609593 @default.
- W2043291671 cites W2086454098 @default.
- W2043291671 cites W2088192427 @default.
- W2043291671 cites W2089204801 @default.
- W2043291671 cites W2090711753 @default.
- W2043291671 cites W2090925778 @default.
- W2043291671 cites W2097875133 @default.
- W2043291671 cites W2097988818 @default.
- W2043291671 cites W2100503784 @default.
- W2043291671 cites W2103669303 @default.
- W2043291671 cites W2103808218 @default.
- W2043291671 cites W2106829739 @default.
- W2043291671 cites W2107066107 @default.
- W2043291671 cites W2107369528 @default.
- W2043291671 cites W2107805776 @default.
- W2043291671 cites W2110389012 @default.
- W2043291671 cites W2115800864 @default.
- W2043291671 cites W2116846792 @default.
- W2043291671 cites W2120499377 @default.
- W2043291671 cites W2123813486 @default.
- W2043291671 cites W2126078533 @default.
- W2043291671 cites W2127922913 @default.
- W2043291671 cites W2131781913 @default.
- W2043291671 cites W2135717147 @default.