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- W2043292579 abstract "<b><i>Background:</i></b> In descriptive epidemiological studies, investigators must screen large numbers of individuals. How one best screens populations for essential tremor (ET); however, remains an open question. The collection of a standardized writing sample (e.g., a hand-drawn spiral) is a method with many practical advantages, yet there are virtually no data on the validity of this particular method. <b><i>Methods:</i></b> Four hand-drawn spirals (2 right, 2 left) were collected from 831 ET cases across four distinct study settings (population-based study, family study, environmental epidemiological study, brain repository) and, in two of these studies, from 697 controls. Spirals were rated (range 0-3) by a senior movement disorder neurologist. These 1,528 participants also underwent a detailed neurological examination, and total tremor scores (range 0-36) and ET diagnoses were assigned by the neurologist. <b><i>Results:</i></b> The proportion of cases with hand-drawn spiral ratings ≥1.5 in either arm ranged from 78.8-97.0%; only 4.7% of controls had spirals with tremor of that severity. The hand-drawn spiral rating was highly correlated with the total tremor score (r = 0.65-0.73, p < 0.001). <b><i>Conclusions:</i></b> The hand-drawn spiral is a sensitive and specific method of screening for ET. Furthermore, it serves as a valid measure of overall tremor severity." @default.
- W2043292579 created "2016-06-24" @default.
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- W2043292579 date "2015-01-01" @default.
- W2043292579 modified "2023-10-02" @default.
- W2043292579 title "Utility of the Hand-Drawn Spiral as a Tool in Clinical-Epidemiological Research on Essential Tremor: Data from Four Essential Tremor Cohorts" @default.
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- W2043292579 doi "https://doi.org/10.1159/000371850" @default.
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