FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043294920> ?p ?o ?g. }

• W2043294920 endingPage "13" @default.
• W2043294920 startingPage "7" @default.
• W2043294920 abstract "Disulfiram (Antabuse®) is one of several aldehyde dehydrogenase (ALDH) inhibitors that raise the plasma level of acetaldehyde following ethanol ingestion. The usually pleasant reaction to ethanol is thereby changed to an unpleasant one, owing to a number of bodily reactions to acetaldehyde. Populations showing genetic polymorphism with a lack of some isozymes of ALDH have exhibited an intolerance to ethanol similar to that seen with disulfiram. A normal isozyme pattern seems to be a prerequisite for the development of alcoholism, which supports the principle of disulfiram treatment. Disulfiram is an irreversible ALDH inhibitor when administered in vivo. Diethylthiomethylcarbamate (Me-DTC) is formed from disulfiram in three metabolic steps. This compound and two further oxidized metabolites appear to be active metabolites of disulfiram. Measurements of plasma Me-DTC or the reduction of leucocyte ALDH 1 activity may be valuable markers for the proper dose titration of disulfiram and the rational use of this drug. Some toxicological points are discussed." @default.
• W2043294920 created "2016-06-24" @default.
• W2043294920 creator A5064775620 @default.
• W2043294920 date "1992-11-01" @default.
• W2043294920 modified "2023-10-17" @default.
• W2043294920 title "The pharmacology and toxicology of disulfiram and its metabolites" @default.
• W2043294920 cites W1485154422 @default.
• W2043294920 cites W1541676655 @default.
• W2043294920 cites W1966782765 @default.
• W2043294920 cites W1973487017 @default.
• W2043294920 cites W1973920285 @default.
• W2043294920 cites W1975752261 @default.
• W2043294920 cites W1977605528 @default.
• W2043294920 cites W1979209836 @default.
• W2043294920 cites W1982315272 @default.
• W2043294920 cites W1986335875 @default.
• W2043294920 cites W1996242003 @default.
• W2043294920 cites W1998227260 @default.
• W2043294920 cites W2010645926 @default.
• W2043294920 cites W2012882007 @default.
• W2043294920 cites W2017547223 @default.
• W2043294920 cites W2025069994 @default.
• W2043294920 cites W2033189408 @default.
• W2043294920 cites W2034409026 @default.
• W2043294920 cites W2035121831 @default.
• W2043294920 cites W2035210915 @default.
• W2043294920 cites W2049983980 @default.
• W2043294920 cites W2050480334 @default.
• W2043294920 cites W2051202412 @default.
• W2043294920 cites W2056898257 @default.
• W2043294920 cites W2057475910 @default.
• W2043294920 cites W2067176696 @default.
• W2043294920 cites W2070195844 @default.
• W2043294920 cites W2089018811 @default.
• W2043294920 cites W2089276931 @default.
• W2043294920 cites W2100231902 @default.
• W2043294920 cites W2107726328 @default.
• W2043294920 cites W2118148540 @default.
• W2043294920 cites W2123656061 @default.
• W2043294920 cites W2130737278 @default.
• W2043294920 cites W2142191787 @default.
• W2043294920 cites W2343438454 @default.
• W2043294920 cites W2415711058 @default.
• W2043294920 cites W2439771414 @default.
• W2043294920 cites W4236852867 @default.
• W2043294920 cites W4242442617 @default.
• W2043294920 doi "https://doi.org/10.1111/j.1600-0447.1992.tb03309.x" @default.
• W2043294920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1471556" @default.
• W2043294920 hasPublicationYear "1992" @default.
• W2043294920 type Work @default.
• W2043294920 sameAs 2043294920 @default.
• W2043294920 citedByCount "100" @default.
• W2043294920 countsByYear W20432949202012 @default.
• W2043294920 countsByYear W20432949202013 @default.
• W2043294920 countsByYear W20432949202014 @default.
• W2043294920 countsByYear W20432949202015 @default.
• W2043294920 countsByYear W20432949202016 @default.
• W2043294920 countsByYear W20432949202017 @default.
• W2043294920 countsByYear W20432949202018 @default.
• W2043294920 countsByYear W20432949202019 @default.
• W2043294920 countsByYear W20432949202020 @default.
• W2043294920 countsByYear W20432949202021 @default.
• W2043294920 countsByYear W20432949202022 @default.
• W2043294920 countsByYear W20432949202023 @default.
• W2043294920 crossrefType "journal-article" @default.
• W2043294920 hasAuthorship W2043294920A5064775620 @default.
• W2043294920 hasConcept C119795356 @default.
• W2043294920 hasConcept C181199279 @default.
• W2043294920 hasConcept C185592680 @default.
• W2043294920 hasConcept C207001950 @default.
• W2043294920 hasConcept C25747580 @default.
• W2043294920 hasConcept C2777344606 @default.
• W2043294920 hasConcept C2777595113 @default.
• W2043294920 hasConcept C2778523461 @default.
• W2043294920 hasConcept C2780035454 @default.
• W2043294920 hasConcept C2780161600 @default.
• W2043294920 hasConcept C2781066024 @default.
• W2043294920 hasConcept C3175096 @default.
• W2043294920 hasConcept C54355233 @default.
• W2043294920 hasConcept C55493867 @default.
• W2043294920 hasConcept C71924100 @default.
• W2043294920 hasConcept C86803240 @default.
• W2043294920 hasConcept C98274493 @default.
• W2043294920 hasConceptScore W2043294920C119795356 @default.
• W2043294920 hasConceptScore W2043294920C181199279 @default.
• W2043294920 hasConceptScore W2043294920C185592680 @default.
• W2043294920 hasConceptScore W2043294920C207001950 @default.
• W2043294920 hasConceptScore W2043294920C25747580 @default.
• W2043294920 hasConceptScore W2043294920C2777344606 @default.
• W2043294920 hasConceptScore W2043294920C2777595113 @default.
• W2043294920 hasConceptScore W2043294920C2778523461 @default.
• W2043294920 hasConceptScore W2043294920C2780035454 @default.
• W2043294920 hasConceptScore W2043294920C2780161600 @default.
• W2043294920 hasConceptScore W2043294920C2781066024 @default.
• W2043294920 hasConceptScore W2043294920C3175096 @default.
• W2043294920 hasConceptScore W2043294920C54355233 @default.
• W2043294920 hasConceptScore W2043294920C55493867 @default.
• W2043294920 hasConceptScore W2043294920C71924100 @default.

• next