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- W2043295080 abstract "The description of the molecular pathogenesis of acute myeloid leukemias (AML) has seen dramatic progress over the last years. Two major types of genetic events have been described that are crucial for leukemic transformation: alterations in myeloid transcription factors governing hematopoietic differentiation and activating mutations of signal transduction intermediates. These processes are highly interdependent, since the molecular events changing the transcriptional control in hematopoietic progenitor cells modify the composition of signal transduction molecules available for growth factor receptors, while the activating mutations in signal transduction molecules induce alterations in the activity and expression of several transcription factors that are crucial for normal myeloid differentiation. The purpose of this article is to review the current literature describing these genetic events, their biological consequences and their clinical implications. As the article will show, the recent description of several critical transforming mutations in AML may soon give rise to more efficient and less toxic molecularly targeted therapies of this deadly disease." @default.
- W2043295080 created "2016-06-24" @default.
- W2043295080 creator A5025105470 @default.
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- W2043295080 creator A5075606110 @default.
- W2043295080 creator A5086016311 @default.
- W2043295080 date "2005-11-01" @default.
- W2043295080 modified "2023-09-30" @default.
- W2043295080 title "The molecular pathogenesis of acute myeloid leukemia" @default.
- W2043295080 cites W108809021 @default.
- W2043295080 cites W11751756 @default.
- W2043295080 cites W129269179 @default.
- W2043295080 cites W134922517 @default.
- W2043295080 cites W1428006903 @default.
- W2043295080 cites W148052780 @default.
- W2043295080 cites W1483582136 @default.
- W2043295080 cites W1486112083 @default.
- W2043295080 cites W1486948598 @default.
- W2043295080 cites W1489323849 @default.
- W2043295080 cites W1502074492 @default.
- W2043295080 cites W1504158565 @default.
- W2043295080 cites W1506423591 @default.
- W2043295080 cites W1508593718 @default.
- W2043295080 cites W1510833310 @default.
- W2043295080 cites W1511815964 @default.
- W2043295080 cites W1531836615 @default.
- W2043295080 cites W1542395305 @default.
- W2043295080 cites W1550565578 @default.
- W2043295080 cites W1553544241 @default.
- W2043295080 cites W1558080846 @default.
- W2043295080 cites W1558535920 @default.
- W2043295080 cites W1570936479 @default.
- W2043295080 cites W1583035638 @default.
- W2043295080 cites W1585517331 @default.
- W2043295080 cites W159302622 @default.
- W2043295080 cites W1594364161 @default.
- W2043295080 cites W1654498070 @default.
- W2043295080 cites W168754456 @default.
- W2043295080 cites W1739103212 @default.
- W2043295080 cites W1790518863 @default.
- W2043295080 cites W188006079 @default.
- W2043295080 cites W1885288630 @default.
- W2043295080 cites W1906973978 @default.
- W2043295080 cites W193532439 @default.
- W2043295080 cites W1941286715 @default.
- W2043295080 cites W1948730391 @default.
- W2043295080 cites W1964103753 @default.
- W2043295080 cites W1964244556 @default.
- W2043295080 cites W1965186008 @default.
- W2043295080 cites W1966345591 @default.
- W2043295080 cites W1968306285 @default.
- W2043295080 cites W1969218281 @default.
- W2043295080 cites W1969366020 @default.
- W2043295080 cites W1971056717 @default.
- W2043295080 cites W1971833736 @default.
- W2043295080 cites W1971834102 @default.
- W2043295080 cites W19721907 @default.
- W2043295080 cites W1973023394 @default.
- W2043295080 cites W1975636695 @default.
- W2043295080 cites W1976386009 @default.
- W2043295080 cites W1977355465 @default.
- W2043295080 cites W1977472414 @default.
- W2043295080 cites W1978469902 @default.
- W2043295080 cites W1978544029 @default.
- W2043295080 cites W1978589349 @default.
- W2043295080 cites W1978798502 @default.
- W2043295080 cites W1979895333 @default.
- W2043295080 cites W1980771751 @default.
- W2043295080 cites W1981709629 @default.
- W2043295080 cites W1982315838 @default.
- W2043295080 cites W1982342754 @default.
- W2043295080 cites W1982721874 @default.
- W2043295080 cites W1983631422 @default.
- W2043295080 cites W1983751803 @default.
- W2043295080 cites W1984486504 @default.
- W2043295080 cites W1984565556 @default.
- W2043295080 cites W1984607452 @default.
- W2043295080 cites W1985336179 @default.
- W2043295080 cites W1985540245 @default.
- W2043295080 cites W1986409528 @default.
- W2043295080 cites W1986527340 @default.
- W2043295080 cites W1987598864 @default.
- W2043295080 cites W1988345778 @default.
- W2043295080 cites W1989145865 @default.
- W2043295080 cites W1989604472 @default.
- W2043295080 cites W1990030298 @default.
- W2043295080 cites W1991419585 @default.
- W2043295080 cites W1991766825 @default.
- W2043295080 cites W1992804384 @default.
- W2043295080 cites W1992900193 @default.
- W2043295080 cites W1992945955 @default.
- W2043295080 cites W1992965385 @default.
- W2043295080 cites W1993726301 @default.
- W2043295080 cites W1994987603 @default.
- W2043295080 cites W1995142305 @default.
- W2043295080 cites W1996501345 @default.
- W2043295080 cites W1996606746 @default.