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- W2043296062 abstract "Vemurafenib interrupts the BRAF/MEK/ERK pathway in melanomas that harbour the BRAF V600E mutation (present in about 50% of patients). The addition of cobimetinib, a MEK inhibitor, to vemurafenib might prevent or delay the onset of resistance. In a previous open-label, phase 1b trial, 66 vemurafenib-refractory patients and 63 BRAF-inhibitor-naive patients with BRAF V600 mutation-positive metastatic melanoma were treated with the combination vemurafanib and cobimetinib. In treatment-naive patients, median progression-free survival was 13·7 months, 87% of patients had an overall response, and 10% a complete response." @default.
- W2043296062 created "2016-06-24" @default.
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- W2043296062 date "2014-11-01" @default.
- W2043296062 modified "2023-09-25" @default.
- W2043296062 title "Vemurafenib and cobimetinib in BRAF-mutated melanoma" @default.
- W2043296062 doi "https://doi.org/10.1016/s1470-2045(14)71023-x" @default.
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