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- W2043302287 endingPage "573" @default.
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- W2043302287 abstract "During development and aging, animals suffer insults that modify the fitness of individual cells. In Drosophila, the elimination of viable but suboptimal cells is mediated by cell competition, ensuring that these cells do not accumulate during development. In addition, certain genes such as the Drosophila homolog of human c-myc (dmyc) are able to transform cells into supercompetitors, which eliminate neighboring wild-type cells by apoptosis and overproliferate, leaving total cell numbers unchanged. Here we have identified Drosophila Sparc as an early marker transcriptionally upregulated in loser cells that provides a transient protection by inhibiting Caspase activation in outcompeted cells. Overall, we describe the unexpected existence of a physiological mechanism that counteracts cell competition during development." @default.
- W2043302287 created "2016-06-24" @default.
- W2043302287 creator A5010497283 @default.
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- W2043302287 date "2010-10-01" @default.
- W2043302287 modified "2023-10-17" @default.
- W2043302287 title "Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition" @default.
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- W2043302287 doi "https://doi.org/10.1016/j.devcel.2010.09.004" @default.
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