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- W2043306210 abstract "Chronic unproductive coughing and dyspnea are symptoms that severely diminish the quality of life in a substantial proportion of the population. There are presently few if any drugs that effectively treat these symptoms. Rational drug targets for cough and dyspnea have emerged over the recent years based on developments in our understanding of the innervation of the respiratory tract. These drug targets can be subcategorized into those that target the vagal afferent nerve endings, and those that target neural activity within the CNS. This review focuses on targets presumed to be in the peripheral terminals of afferent nerves within the airways. Conceptually, the activity of peripheral afferent nerves involved with unwanted urge-to-cough or dyspnea sensations can be inhibited by limiting the intensity of the stimulus, inhibiting the amplitude of the stimulus-induced generator potential, or inhibiting the transduction between the generator potential and action potential discharge and conduction. These mechanisms reveal many therapeutic strategies for anti-tussive and anti-dyspnea drug development with peripheral sites of action." @default.
- W2043306210 created "2016-06-24" @default.
- W2043306210 creator A5004911440 @default.
- W2043306210 creator A5051085724 @default.
- W2043306210 date "2011-06-01" @default.
- W2043306210 modified "2023-09-23" @default.
- W2043306210 title "Targeting peripheral afferent nerve terminals for cough and dyspnea" @default.
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- W2043306210 doi "https://doi.org/10.1016/j.coph.2011.05.006" @default.
- W2043306210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3151737" @default.
- W2043306210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21705272" @default.
- W2043306210 hasPublicationYear "2011" @default.
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