FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043322963> ?p ?o ?g. }

• W2043322963 endingPage "616" @default.
• W2043322963 startingPage "611" @default.
• W2043322963 abstract "It has recently been recognised that anticancer chemotherapy can elicit an immunogenic form of apoptosis characterised by the exposure of calreticulin (CRT) on the surface of dying tumour cells, entailing an immune response that contributes to the therapeutic outcome. CRT exposure has been found to be induced by anthracyclins and oxaliplatin, but not by other proapoptotic antineoplastic agents including etoposide, camptothecin and cisplatin. In this study, we examined the histone deacetylase inhibitor vorinostat for its capability to stimulate CRT exposure in tumour cells. Childhood tumour cells, i.e. the brain tumour cell lines PFSK and DAOY and the Ewing’s sarcoma cell line CADO-ES-1, were treated with vorinostat, and CRT exposure was determined by flow cytometric analysis of CRT immunofluorescence. Combination effects of vorinostat/TRAIL and vorinostat/bortezomib were also assessed. Vorinostat treatment induced CRT exposure in PFSK and DAOY cells, but not in caspase-8-deficient CADO-ES-1 cells. CRT exposure could be prevented by the pan-caspase inhibitor z-VAD-fmk and by brefeldin A, an inhibitor of Golgi-mediated transport. Vorinostat has the capacity to elicit CRT exposure, suggesting its usefulness as immunogenic antitumour agent." @default.
• W2043322963 created "2016-06-24" @default.
• W2043322963 creator A5013238387 @default.
• W2043322963 creator A5024898786 @default.
• W2043322963 creator A5032504142 @default.
• W2043322963 creator A5054884221 @default.
• W2043322963 creator A5055154765 @default.
• W2043322963 creator A5084313307 @default.
• W2043322963 date "2010-03-10" @default.
• W2043322963 modified "2023-10-16" @default.
• W2043322963 title "The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro" @default.
• W2043322963 cites W1481633630 @default.
• W2043322963 cites W1964372470 @default.
• W2043322963 cites W1965313675 @default.
• W2043322963 cites W1967329857 @default.
• W2043322963 cites W1983645982 @default.
• W2043322963 cites W1987331911 @default.
• W2043322963 cites W2006277656 @default.
• W2043322963 cites W2016612145 @default.
• W2043322963 cites W2018992636 @default.
• W2043322963 cites W2029963000 @default.
• W2043322963 cites W2062040583 @default.
• W2043322963 cites W2083093250 @default.
• W2043322963 cites W2083991703 @default.
• W2043322963 cites W2091103707 @default.
• W2043322963 cites W2095472825 @default.
• W2043322963 cites W2102650381 @default.
• W2043322963 cites W2113195478 @default.
• W2043322963 cites W2139607151 @default.
• W2043322963 cites W2144991849 @default.
• W2043322963 cites W2149247636 @default.
• W2043322963 cites W2152904585 @default.
• W2043322963 cites W2159959495 @default.
• W2043322963 doi "https://doi.org/10.1007/s00280-010-1302-4" @default.
• W2043322963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20221600" @default.
• W2043322963 hasPublicationYear "2010" @default.
• W2043322963 type Work @default.
• W2043322963 sameAs 2043322963 @default.
• W2043322963 citedByCount "24" @default.
• W2043322963 countsByYear W20433229632012 @default.
• W2043322963 countsByYear W20433229632013 @default.
• W2043322963 countsByYear W20433229632014 @default.
• W2043322963 countsByYear W20433229632015 @default.
• W2043322963 countsByYear W20433229632016 @default.
• W2043322963 countsByYear W20433229632018 @default.
• W2043322963 countsByYear W20433229632019 @default.
• W2043322963 countsByYear W20433229632020 @default.
• W2043322963 countsByYear W20433229632021 @default.
• W2043322963 countsByYear W20433229632022 @default.
• W2043322963 crossrefType "journal-article" @default.
• W2043322963 hasAuthorship W2043322963A5013238387 @default.
• W2043322963 hasAuthorship W2043322963A5024898786 @default.
• W2043322963 hasAuthorship W2043322963A5032504142 @default.
• W2043322963 hasAuthorship W2043322963A5054884221 @default.
• W2043322963 hasAuthorship W2043322963A5055154765 @default.
• W2043322963 hasAuthorship W2043322963A5084313307 @default.
• W2043322963 hasBestOaLocation W20433229632 @default.
• W2043322963 hasConcept C104317684 @default.
• W2043322963 hasConcept C158617107 @default.
• W2043322963 hasConcept C190283241 @default.
• W2043322963 hasConcept C2776202225 @default.
• W2043322963 hasConcept C2776262904 @default.
• W2043322963 hasConcept C2777877232 @default.
• W2043322963 hasConcept C2778305200 @default.
• W2043322963 hasConcept C2779682216 @default.
• W2043322963 hasConcept C31573885 @default.
• W2043322963 hasConcept C47450691 @default.
• W2043322963 hasConcept C502942594 @default.
• W2043322963 hasConcept C55493867 @default.
• W2043322963 hasConcept C64927066 @default.
• W2043322963 hasConcept C86803240 @default.
• W2043322963 hasConcept C95444343 @default.
• W2043322963 hasConcept C98274493 @default.
• W2043322963 hasConceptScore W2043322963C104317684 @default.
• W2043322963 hasConceptScore W2043322963C158617107 @default.
• W2043322963 hasConceptScore W2043322963C190283241 @default.
• W2043322963 hasConceptScore W2043322963C2776202225 @default.
• W2043322963 hasConceptScore W2043322963C2776262904 @default.
• W2043322963 hasConceptScore W2043322963C2777877232 @default.
• W2043322963 hasConceptScore W2043322963C2778305200 @default.
• W2043322963 hasConceptScore W2043322963C2779682216 @default.
• W2043322963 hasConceptScore W2043322963C31573885 @default.
• W2043322963 hasConceptScore W2043322963C47450691 @default.
• W2043322963 hasConceptScore W2043322963C502942594 @default.
• W2043322963 hasConceptScore W2043322963C55493867 @default.
• W2043322963 hasConceptScore W2043322963C64927066 @default.
• W2043322963 hasConceptScore W2043322963C86803240 @default.
• W2043322963 hasConceptScore W2043322963C95444343 @default.
• W2043322963 hasConceptScore W2043322963C98274493 @default.
• W2043322963 hasIssue "3" @default.
• W2043322963 hasLocation W20433229631 @default.
• W2043322963 hasLocation W20433229632 @default.
• W2043322963 hasLocation W20433229633 @default.
• W2043322963 hasLocation W20433229634 @default.
• W2043322963 hasOpenAccess W2043322963 @default.
• W2043322963 hasPrimaryLocation W20433229631 @default.
• W2043322963 hasRelatedWork W2043322963 @default.
• W2043322963 hasRelatedWork W2058270531 @default.

• next