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• W2043336768 abstract "Stroke is one of the leading causes of mortality and morbidity, with astronomical financial repercussions on health systems worldwide. Ischaemic stroke accounts for approximately 80–85% of all cases and is characterised by the disruption of cerebral blood flow and lack of oxygen to the affected area. Oxidative stress culminates due to an imbalance between pro-oxidants and antioxidants and consequent excessive production of reactive oxygen species. Reactive oxygen species are biphasic, playing a role in normal physiological processes and are also implicated in a number of disease processes, whereby they mediate damage to cell structures, including lipids, membranes, proteins, and DNA. The cerebral vasculature is a major target of oxidative stress playing a critical role in the pathogenesis of ischaemic brain injury following a cerebrovascular attack. Superoxide, the primary reactive oxygen species, and its derivatives have been shown to cause vasodilatation via the opening of potassium channels and altered vascular reactivity, breakdown of the blood-brain barrier and focal destructive lesions in animal models of ischaemic stroke. However, reactive oxygen species are involved in normal physiological processes including cell signalling, induction of mitogenesis, and immune defence. Primarily, this review will focus on the cellular and vascular aspects of reactive oxygen and nitrogen species generation and their role in the pathogenesis of ischaemia–reperfusion phenomena. Secondly, the proposed mechanisms of oxidative stress-related neuronal death will be reflected upon and in summation specific targeted neuroprotective therapies targetting oxidative stress and their role in the pathogenesis of stroke will be discussed." @default.
• W2043336768 created "2016-06-24" @default.
• W2043336768 creator A5011130143 @default.
• W2043336768 creator A5074601608 @default.
• W2043336768 date "2009-12-01" @default.
• W2043336768 modified "2023-10-11" @default.
• W2043336768 title "Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke" @default.
• W2043336768 cites W1519248623 @default.
• W2043336768 cites W1525942467 @default.
• W2043336768 cites W1553299262 @default.
• W2043336768 cites W1572780831 @default.
• W2043336768 cites W1579177515 @default.
• W2043336768 cites W1635047156 @default.
• W2043336768 cites W1965476204 @default.
• W2043336768 cites W1966370003 @default.
• W2043336768 cites W1968037251 @default.
• W2043336768 cites W1972317764 @default.
• W2043336768 cites W1978136794 @default.
• W2043336768 cites W1978348298 @default.
• W2043336768 cites W1979030376 @default.
• W2043336768 cites W1979561481 @default.
• W2043336768 cites W1994433120 @default.
• W2043336768 cites W1994903514 @default.
• W2043336768 cites W1996716971 @default.
• W2043336768 cites W1996871253 @default.
• W2043336768 cites W1999712695 @default.
• W2043336768 cites W2000356591 @default.
• W2043336768 cites W2002490462 @default.
• W2043336768 cites W2003672697 @default.
• W2043336768 cites W2003696679 @default.
• W2043336768 cites W2004690434 @default.
• W2043336768 cites W2005675003 @default.
• W2043336768 cites W2007120708 @default.
• W2043336768 cites W2007333100 @default.
• W2043336768 cites W2010724383 @default.
• W2043336768 cites W2016575029 @default.
• W2043336768 cites W2016597337 @default.
• W2043336768 cites W2019126109 @default.
• W2043336768 cites W2024129161 @default.
• W2043336768 cites W2026742692 @default.
• W2043336768 cites W2029652412 @default.
• W2043336768 cites W2034991523 @default.
• W2043336768 cites W2038383414 @default.
• W2043336768 cites W2040852689 @default.
• W2043336768 cites W2041253555 @default.
• W2043336768 cites W2042482256 @default.
• W2043336768 cites W2043675475 @default.
• W2043336768 cites W2044928798 @default.
• W2043336768 cites W2048330053 @default.
• W2043336768 cites W2049696886 @default.
• W2043336768 cites W2053007566 @default.
• W2043336768 cites W2057825180 @default.
• W2043336768 cites W2058823140 @default.
• W2043336768 cites W2059786916 @default.
• W2043336768 cites W2061152334 @default.
• W2043336768 cites W2065213941 @default.
• W2043336768 cites W2070763907 @default.
• W2043336768 cites W2071973579 @default.
• W2043336768 cites W2080279037 @default.
• W2043336768 cites W2082366457 @default.
• W2043336768 cites W2082466337 @default.
• W2043336768 cites W2084744910 @default.
• W2043336768 cites W2085106588 @default.
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• W2043336768 cites W2087042403 @default.
• W2043336768 cites W2088779159 @default.
• W2043336768 cites W2092027247 @default.
• W2043336768 cites W2093941530 @default.
• W2043336768 cites W2098459090 @default.
• W2043336768 cites W2098876918 @default.
• W2043336768 cites W2118489020 @default.
• W2043336768 cites W2119485597 @default.
• W2043336768 cites W2122965222 @default.
• W2043336768 cites W2124240657 @default.
• W2043336768 cites W2124370504 @default.
• W2043336768 cites W2137405058 @default.
• W2043336768 cites W2138662986 @default.
• W2043336768 cites W2148959908 @default.
• W2043336768 cites W2149419595 @default.
• W2043336768 cites W2152788288 @default.
• W2043336768 cites W2152798629 @default.
• W2043336768 cites W2153341085 @default.
• W2043336768 cites W2157698069 @default.
• W2043336768 cites W2161096279 @default.
• W2043336768 cites W2163999595 @default.
• W2043336768 cites W2165201727 @default.
• W2043336768 cites W2175642831 @default.
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• W2043336768 cites W2230430502 @default.
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• W2043336768 doi "https://doi.org/10.1111/j.1747-4949.2009.00387.x" @default.
• W2043336768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19930058" @default.
• W2043336768 hasPublicationYear "2009" @default.
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