FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043387802> ?p ?o ?g. }

• W2043387802 endingPage "385" @default.
• W2043387802 startingPage "371" @default.
• W2043387802 abstract "The genotype-phenotype (GP) map consists of developmental and physiological mechanisms mapping genetic onto phenotypic variation. It determines the distribution of heritable phenotypic variance on which selection can act. Comparative studies of morphology as well as of gene regulatory networks show that the GP map itself evolves, yet little is known about the actual evolutionary mechanisms involved. The study of such mechanisms requires exploring the variation in GP maps at the population level, which presently is easier to quantify by statistical genetic methods rather than by regulatory network structures. We focus on the evolution of pleiotropy, a major structural aspect of the GP map. Pleiotropic genes affect multiple traits and underlie genetic covariance between traits, often causing evolutionary constraints. Previous quantitative genetic studies have demonstrated population-level variation in pleiotropy in the form of loci, at which genotypes differ in the genetic covariation between traits. This variation can potentially fuel evolution of the GP map under selection and/or drift. Here, we propose a developmental mechanism underlying population genetic variation in covariance and test its predictions. Specifically, the mechanism predicts that the loci identified as responsible for genetic variation in pleiotropy are involved in trait-specific epistatic interactions. We test this prediction for loci affecting allometric relationships between traits in an advanced intercross between inbred mouse strains. The results consistently support the prediction. We further find a high degree of sign epistasis in these interactions, which we interpret as an indication of adaptive gene complexes within the diverged parental lines." @default.
• W2043387802 created "2016-06-24" @default.
• W2043387802 creator A5001409441 @default.
• W2043387802 creator A5032652974 @default.
• W2043387802 creator A5036985075 @default.
• W2043387802 creator A5087500022 @default.
• W2043387802 date "2011-04-01" @default.
• W2043387802 modified "2023-10-14" @default.
• W2043387802 title "Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map" @default.
• W2043387802 cites W1965598885 @default.
• W2043387802 cites W1967602433 @default.
• W2043387802 cites W1975301692 @default.
• W2043387802 cites W1985938067 @default.
• W2043387802 cites W2004311967 @default.
• W2043387802 cites W2011145067 @default.
• W2043387802 cites W2020766456 @default.
• W2043387802 cites W2030380201 @default.
• W2043387802 cites W2032011454 @default.
• W2043387802 cites W2032490269 @default.
• W2043387802 cites W2034265459 @default.
• W2043387802 cites W2034608799 @default.
• W2043387802 cites W2039568484 @default.
• W2043387802 cites W2051603200 @default.
• W2043387802 cites W2057916769 @default.
• W2043387802 cites W2060399360 @default.
• W2043387802 cites W2060459591 @default.
• W2043387802 cites W2061461085 @default.
• W2043387802 cites W2073001251 @default.
• W2043387802 cites W2076575251 @default.
• W2043387802 cites W2077723503 @default.
• W2043387802 cites W2078513539 @default.
• W2043387802 cites W2080433180 @default.
• W2043387802 cites W2082692364 @default.
• W2043387802 cites W2092163517 @default.
• W2043387802 cites W2093403092 @default.
• W2043387802 cites W2093896273 @default.
• W2043387802 cites W2095413266 @default.
• W2043387802 cites W2095627229 @default.
• W2043387802 cites W2105561568 @default.
• W2043387802 cites W2105581010 @default.
• W2043387802 cites W2105942598 @default.
• W2043387802 cites W2107755054 @default.
• W2043387802 cites W2115912742 @default.
• W2043387802 cites W2117851139 @default.
• W2043387802 cites W2119632054 @default.
• W2043387802 cites W2121331980 @default.
• W2043387802 cites W2123755994 @default.
• W2043387802 cites W2126796035 @default.
• W2043387802 cites W2131302950 @default.
• W2043387802 cites W2131690896 @default.
• W2043387802 cites W2132979925 @default.
• W2043387802 cites W2133924585 @default.
• W2043387802 cites W2133999074 @default.
• W2043387802 cites W2136718483 @default.
• W2043387802 cites W2140349867 @default.
• W2043387802 cites W2140374826 @default.
• W2043387802 cites W2141553269 @default.
• W2043387802 cites W2142909665 @default.
• W2043387802 cites W2145953174 @default.
• W2043387802 cites W2146513173 @default.
• W2043387802 cites W2146707484 @default.
• W2043387802 cites W2146849562 @default.
• W2043387802 cites W2149915402 @default.
• W2043387802 cites W2152556669 @default.
• W2043387802 cites W2153828784 @default.
• W2043387802 cites W2155496693 @default.
• W2043387802 cites W2155762441 @default.
• W2043387802 cites W2161376294 @default.
• W2043387802 cites W2163285329 @default.
• W2043387802 cites W2170983691 @default.
• W2043387802 cites W2171137191 @default.
• W2043387802 cites W2224154267 @default.
• W2043387802 cites W2262172230 @default.
• W2043387802 cites W2264185383 @default.
• W2043387802 cites W2276231249 @default.
• W2043387802 cites W2314959992 @default.
• W2043387802 cites W2324609106 @default.
• W2043387802 cites W2324668910 @default.
• W2043387802 cites W2335268614 @default.
• W2043387802 cites W4238523857 @default.
• W2043387802 cites W4248367191 @default.
• W2043387802 cites W4297888675 @default.
• W2043387802 cites W4376522535 @default.
• W2043387802 doi "https://doi.org/10.1002/jez.b.21410" @default.
• W2043387802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3112255" @default.
• W2043387802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21462316" @default.
• W2043387802 hasPublicationYear "2011" @default.
• W2043387802 type Work @default.
• W2043387802 sameAs 2043387802 @default.
• W2043387802 citedByCount "41" @default.
• W2043387802 countsByYear W20433878022012 @default.
• W2043387802 countsByYear W20433878022013 @default.
• W2043387802 countsByYear W20433878022014 @default.
• W2043387802 countsByYear W20433878022015 @default.
• W2043387802 countsByYear W20433878022016 @default.
• W2043387802 countsByYear W20433878022017 @default.
• W2043387802 countsByYear W20433878022018 @default.
• W2043387802 countsByYear W20433878022019 @default.

• next