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- W2043399309 abstract "The metabolic fate of high density lipoprotein (HDL) sphingomyelin in plasma was studied in rats over a 24-hr period after injection of HDL containing sphingomyelin which was14C-labeled in the stearic (18∶0) or lignoceric acid (24∶0) moiety and3H-labeled in the choline methyl groups. Decay of label in plasma followed three phases. The first two phases were similar for both isotopes and both types of sphingomyelin (t1/2≃10 and 110 min). However, during the third phase (from 10 hr after injection),3H label disappeared more slowly than14C label from 18∶0 sphingomyelin, whereas the3H/14C ratio remained relatively constant when 24∶0 sphingomyelin was used. Intact, doubly-labeled 18∶0 sphingomyelin disappeared from HDL rapidly (t1/2=38 min) by tissue uptake and by transfer to very low density lipoprotein (VLDL). VLDL contained up to 12% of the sphingomyelin 1 hr after injection. This is the first demonstration of a transferin vivo of sphingomyelin from HDL to VLDL. A similarly rapid transfer was also observedin vitro. Some nontritated, [14C]18∶0 or [14C]24∶0 sphingomyelin was redistributed more slowly into HDL. Doubly-labeled phosphatidylcholine appeared in VLDL and HDL within 1 hr after injection and reached 1.8 and 2.1% of the injected14C and3H in VLDL at 1 hr, and 4.8 and 6.9% in HDL at 3 hr, respectively." @default.
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- W2043399309 date "1990-10-01" @default.
- W2043399309 modified "2023-09-26" @default.
- W2043399309 title "Metabolic fate of sphingomyelin of high-density lipoprotein in rat plasma" @default.
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- W2043399309 doi "https://doi.org/10.1007/bf02536017" @default.
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