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• W2043416633 abstract "BACKGROUND The role of Wnt/β-Catenin signaling in embryogenesis and carcinogenesis has been extensively studied in organs such as colon, lung and pancreas, but little is known about Wnt/β-Catenin signaling in the prostate. Although stabilizing mutations in APC and β-Catenin are rare in primary prostate tumors, recent studies suggest that cytoplasmic/nuclear β-Catenin is associated with advanced, metastatic, hormone-refractory prostate carcinoma. METHODS To better understand the role of β-Catenin in prostatic development and carcinogenesis, we studied Wnt expression during prostate development and activated Wnt/β-Catenin signaling in the developing and adult prostate. RESULTS Our results demonstrated that during prostate development Wnt ligands display a dynamic expression pattern. Activation of β-Catenin during prostate development caused epithelial hyperplasia followed by prostatic intraepithelial neoplasia (PIN) in prostate. In the adult prostate, activation of β-Catenin resulted in high grade PIN (HGPIN) and continuous prostatic growth after castration. As a result of activation of β-Catenin, AR was first up-regulated with the emergence of epithelial hyperplasia, but was later down-regulated when HGPIN developed. Furthermore, activation of β-Catenin induced Foxa2 re-expression in adult prostate which normally is only expressed in the embryonic budding stage during prostate development. CONCLUSIONS The results from this study strongly suggest that Wnt/β-Catenin signaling is involved in the regulation of prostate development and confirm that constitutive activation of this pathway enables the mouse prostate to grow after castration. Prostate 69:249–262, 2009. © 2008 Wiley-Liss, Inc." @default.
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• W2043416633 date "2009-02-15" @default.
• W2043416633 modified "2023-10-01" @default.
• W2043416633 title "Activation of β-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration" @default.
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• W2043416633 doi "https://doi.org/10.1002/pros.20877" @default.
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