Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043416800> ?p ?o ?g. }
- W2043416800 endingPage "1562" @default.
- W2043416800 startingPage "1551" @default.
- W2043416800 abstract "The 26S proteasome is a 2.5 MDa molecular machine for the degradation of substrates of the ubiquitin-proteasome pathway with a key role in cellular proteostasis. Until recently, only the structure of its core particle, the 20S proteasome, could be studied in detail, whereas the 19S regulatory particle or the holocomplex remained elusive. Novel integrative approaches have now revealed the molecular architecture of the entire complex and provided the first insights into the conformational changes during its functional cycle. Here we review the problems in structural studies of the 26S proteasome, the methods that made possible its structure determination, the architectural principles of the holocomplex, and its conformational space. These advances provide valuable insights into the mechanism of substrate recruitment and processing preceding their destruction in the 20S core particle." @default.
- W2043416800 created "2016-06-24" @default.
- W2043416800 creator A5023881867 @default.
- W2043416800 creator A5029559203 @default.
- W2043416800 creator A5048721554 @default.
- W2043416800 creator A5073848521 @default.
- W2043416800 date "2013-09-01" @default.
- W2043416800 modified "2023-10-18" @default.
- W2043416800 title "Unveiling the Long-Held Secrets of the 26S Proteasome" @default.
- W2043416800 cites W1258228527 @default.
- W2043416800 cites W136634311 @default.
- W2043416800 cites W1486066462 @default.
- W2043416800 cites W1518640128 @default.
- W2043416800 cites W1525900360 @default.
- W2043416800 cites W1653065940 @default.
- W2043416800 cites W1677689941 @default.
- W2043416800 cites W1755406767 @default.
- W2043416800 cites W1851733051 @default.
- W2043416800 cites W1965667503 @default.
- W2043416800 cites W1967530280 @default.
- W2043416800 cites W1969075925 @default.
- W2043416800 cites W1969435183 @default.
- W2043416800 cites W1969668210 @default.
- W2043416800 cites W1971808532 @default.
- W2043416800 cites W1971841367 @default.
- W2043416800 cites W1975460230 @default.
- W2043416800 cites W1975462016 @default.
- W2043416800 cites W1976878585 @default.
- W2043416800 cites W1977891703 @default.
- W2043416800 cites W1978403153 @default.
- W2043416800 cites W1978496023 @default.
- W2043416800 cites W1980534130 @default.
- W2043416800 cites W1981591191 @default.
- W2043416800 cites W1984553096 @default.
- W2043416800 cites W1985532449 @default.
- W2043416800 cites W1985568538 @default.
- W2043416800 cites W1987262921 @default.
- W2043416800 cites W1988100248 @default.
- W2043416800 cites W1992174702 @default.
- W2043416800 cites W1995068520 @default.
- W2043416800 cites W1996460413 @default.
- W2043416800 cites W1997054994 @default.
- W2043416800 cites W1997827461 @default.
- W2043416800 cites W1999119754 @default.
- W2043416800 cites W2000409052 @default.
- W2043416800 cites W2000489536 @default.
- W2043416800 cites W2000872571 @default.
- W2043416800 cites W2003062513 @default.
- W2043416800 cites W2003924932 @default.
- W2043416800 cites W2006819428 @default.
- W2043416800 cites W2006920169 @default.
- W2043416800 cites W2006975754 @default.
- W2043416800 cites W2008492694 @default.
- W2043416800 cites W2008561447 @default.
- W2043416800 cites W2009187320 @default.
- W2043416800 cites W2012101447 @default.
- W2043416800 cites W2013057562 @default.
- W2043416800 cites W2014630160 @default.
- W2043416800 cites W2016803661 @default.
- W2043416800 cites W2017033636 @default.
- W2043416800 cites W2021296110 @default.
- W2043416800 cites W2023577211 @default.
- W2043416800 cites W2027764374 @default.
- W2043416800 cites W2027971820 @default.
- W2043416800 cites W2031466557 @default.
- W2043416800 cites W2032723541 @default.
- W2043416800 cites W2035533113 @default.
- W2043416800 cites W2035667407 @default.
- W2043416800 cites W2037305493 @default.
- W2043416800 cites W2037592320 @default.
- W2043416800 cites W2037913550 @default.
- W2043416800 cites W2038751264 @default.
- W2043416800 cites W2045533311 @default.
- W2043416800 cites W2046164706 @default.
- W2043416800 cites W2048224115 @default.
- W2043416800 cites W2048240388 @default.
- W2043416800 cites W2052742292 @default.
- W2043416800 cites W2055544854 @default.
- W2043416800 cites W2056020080 @default.
- W2043416800 cites W2056938487 @default.
- W2043416800 cites W2060354742 @default.
- W2043416800 cites W2068134926 @default.
- W2043416800 cites W2070367241 @default.
- W2043416800 cites W2071746920 @default.
- W2043416800 cites W2071804506 @default.
- W2043416800 cites W2072310534 @default.
- W2043416800 cites W2072973641 @default.
- W2043416800 cites W2073158371 @default.
- W2043416800 cites W2075597028 @default.
- W2043416800 cites W2077322822 @default.
- W2043416800 cites W2080063823 @default.
- W2043416800 cites W2080075851 @default.
- W2043416800 cites W2081444617 @default.
- W2043416800 cites W2083611458 @default.
- W2043416800 cites W2085175631 @default.
- W2043416800 cites W2086729572 @default.
- W2043416800 cites W2087019753 @default.
- W2043416800 cites W2087169221 @default.