Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043421089> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2043421089 endingPage "417" @default.
- W2043421089 startingPage "414" @default.
- W2043421089 abstract "The age-dependent characteristics of transdermal permeation of ethyl nicotinate (EN) and its metabolism to nicotinic acid (NA) were examined in rats at the ages of a fetus at 21 d, 3, 10, 50, 270 and 360 d. Skin transport in vitro was investigated using mounted skin in side-by-side diffusion chambers, and flux of EN and NA was determined. With developing and aging in rats, EN flux from EN-saturated solution declined gradually, however, NA flux increased drastically at 10 and 50 d. To elucidate the mechanism of this age-dependent escalation of NA flux, a hydrolysis study was performed using skin homogenate, and the Michaelis-Menten parameters (Vmax and Km) of EN were evaluated. Vmax and Vmax/Km ratio showed the same tendency with NA flux/total (EN+NA) flux ratio, suggesting that skin esterases in rats are developed gradually after birth, then increase markedly and become steady in the adult period. On the other hand, the affinity parameter, Km, was almost the same among all ages. Moreover, metabolic saturation of esterase during the transdermal process occurred in all ages, and maximal NA flux and EN concentration in the donor compartment for the maximal NA flux were also affected by age. These findings indicated that the discrepancy in transdermal profiles of EN among the ages tested was dominantly due to the difference in the development of esterase in the growth process." @default.
- W2043421089 created "2016-06-24" @default.
- W2043421089 creator A5006649741 @default.
- W2043421089 creator A5046756346 @default.
- W2043421089 creator A5082579845 @default.
- W2043421089 creator A5087412950 @default.
- W2043421089 date "2001-01-01" @default.
- W2043421089 modified "2023-10-16" @default.
- W2043421089 title "Age Difference in Simultaneous Permeation and Metabolism of Ethyl Nicotinate in Rat Skin." @default.
- W2043421089 cites W100764428 @default.
- W2043421089 cites W1775749144 @default.
- W2043421089 cites W1973617352 @default.
- W2043421089 cites W1975038083 @default.
- W2043421089 cites W1981224048 @default.
- W2043421089 cites W1984238442 @default.
- W2043421089 cites W1985132866 @default.
- W2043421089 cites W1999345096 @default.
- W2043421089 cites W2000845416 @default.
- W2043421089 cites W2003735503 @default.
- W2043421089 cites W2007520674 @default.
- W2043421089 cites W2008285635 @default.
- W2043421089 cites W2028250332 @default.
- W2043421089 cites W2033959503 @default.
- W2043421089 cites W2035267564 @default.
- W2043421089 cites W2057725524 @default.
- W2043421089 cites W2060425896 @default.
- W2043421089 cites W2062969378 @default.
- W2043421089 cites W2080514897 @default.
- W2043421089 cites W2439733474 @default.
- W2043421089 doi "https://doi.org/10.1248/bpb.24.414" @default.
- W2043421089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11305605" @default.
- W2043421089 hasPublicationYear "2001" @default.
- W2043421089 type Work @default.
- W2043421089 sameAs 2043421089 @default.
- W2043421089 citedByCount "12" @default.
- W2043421089 countsByYear W20434210892014 @default.
- W2043421089 countsByYear W20434210892017 @default.
- W2043421089 countsByYear W20434210892020 @default.
- W2043421089 crossrefType "journal-article" @default.
- W2043421089 hasAuthorship W2043421089A5006649741 @default.
- W2043421089 hasAuthorship W2043421089A5046756346 @default.
- W2043421089 hasAuthorship W2043421089A5082579845 @default.
- W2043421089 hasAuthorship W2043421089A5087412950 @default.
- W2043421089 hasBestOaLocation W20434210891 @default.
- W2043421089 hasConcept C114614502 @default.
- W2043421089 hasConcept C178790620 @default.
- W2043421089 hasConcept C181199279 @default.
- W2043421089 hasConcept C185592680 @default.
- W2043421089 hasConcept C205679159 @default.
- W2043421089 hasConcept C2777261171 @default.
- W2043421089 hasConcept C33923547 @default.
- W2043421089 hasConcept C41625074 @default.
- W2043421089 hasConcept C43617362 @default.
- W2043421089 hasConcept C50670333 @default.
- W2043421089 hasConcept C55493867 @default.
- W2043421089 hasConcept C62231903 @default.
- W2043421089 hasConcept C68709404 @default.
- W2043421089 hasConcept C86803240 @default.
- W2043421089 hasConcept C98274493 @default.
- W2043421089 hasConcept C9930424 @default.
- W2043421089 hasConceptScore W2043421089C114614502 @default.
- W2043421089 hasConceptScore W2043421089C178790620 @default.
- W2043421089 hasConceptScore W2043421089C181199279 @default.
- W2043421089 hasConceptScore W2043421089C185592680 @default.
- W2043421089 hasConceptScore W2043421089C205679159 @default.
- W2043421089 hasConceptScore W2043421089C2777261171 @default.
- W2043421089 hasConceptScore W2043421089C33923547 @default.
- W2043421089 hasConceptScore W2043421089C41625074 @default.
- W2043421089 hasConceptScore W2043421089C43617362 @default.
- W2043421089 hasConceptScore W2043421089C50670333 @default.
- W2043421089 hasConceptScore W2043421089C55493867 @default.
- W2043421089 hasConceptScore W2043421089C62231903 @default.
- W2043421089 hasConceptScore W2043421089C68709404 @default.
- W2043421089 hasConceptScore W2043421089C86803240 @default.
- W2043421089 hasConceptScore W2043421089C98274493 @default.
- W2043421089 hasConceptScore W2043421089C9930424 @default.
- W2043421089 hasIssue "4" @default.
- W2043421089 hasLocation W20434210891 @default.
- W2043421089 hasLocation W20434210892 @default.
- W2043421089 hasOpenAccess W2043421089 @default.
- W2043421089 hasPrimaryLocation W20434210891 @default.
- W2043421089 hasRelatedWork W1792591498 @default.
- W2043421089 hasRelatedWork W2031601119 @default.
- W2043421089 hasRelatedWork W2064059154 @default.
- W2043421089 hasRelatedWork W2075718401 @default.
- W2043421089 hasRelatedWork W2121828422 @default.
- W2043421089 hasRelatedWork W2368004522 @default.
- W2043421089 hasRelatedWork W2533850968 @default.
- W2043421089 hasRelatedWork W334704311 @default.
- W2043421089 hasRelatedWork W4242905879 @default.
- W2043421089 hasRelatedWork W2034744608 @default.
- W2043421089 hasVolume "24" @default.
- W2043421089 isParatext "false" @default.
- W2043421089 isRetracted "false" @default.
- W2043421089 magId "2043421089" @default.
- W2043421089 workType "article" @default.