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- W2043445540 abstract "Two B complex genotypes, B1B1 and B19B19, of outbred line S1, were tested for low and high immune response to GAT, from which four recombinants were recovered: B1B1 GAT-hi and lo, and B19B19 GAT-hi and -lo. Also included in the study were birds of B2B2 genotype with an intermediate level of immune response to GAT.A total of 225 birds of these groups were challenged with the Bryan strain of Rous Sarcoma virus subgroup C, RSV (RAV-7), by inoculation into the wing web at five weeks of age. The B1B1 genotype had the lowest percentage of regressors (17.6%), B19B19 had the highest (42.2%), and the B2B2 genotype was intermediate (23.7%). Combining the results of GAT response over the B1B1 and B19B19 genotypes, 14.0% of GAT-lo and 37.8% of GAT-hi regressed their tumours, respectively. The highly significant (P ≤ 0.01) difference between the combined GAT-hi and -lo groups would suggest that the Rs locus controlling tumour regression induced by the subgroup C virus is closely linked to the region controlling immune response to GAT, but the data also provides evidence that the B-F region of the B complex also plays an important role in RSV-induced tumour regression." @default.
- W2043445540 created "2016-06-24" @default.
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- W2043445540 date "1983-06-01" @default.
- W2043445540 modified "2023-09-24" @default.
- W2043445540 title "GENETIC LINKAGE OF SUBGROUP C ROUS SARCOMA VIRUS-INDUCED TUMOR EXPRESSION IN CHICKENS TO THE IR-GAT LOCUS OF THE B COMPLEX" @default.
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- W2043445540 doi "https://doi.org/10.1111/j.1744-313x.1983.tb00799.x" @default.
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