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• W2043448022 abstract "Objectives: Many studies on endometriosis are focused on peritoneal fluid and immune cells regarding it the most frequent localization in peritoneal cavity. Immune cells potentially posses ability to produce matrix metalloproteinases (MMPs). MMPs belong to zinc dependent lytic enzymes that are responsible for degradation of collagen. This effect can enhance the process of implantation and progression of endometriosis. Tissue inhibitor of matrix metaloproteinase-1 (TIMP-1) is responsible for natural inactivation of MMP-1 by forming inactive complex MMP-1/TIMP-1.Design: In our study we measured MMP-1, TIMP-1 and its complex MMP-1/TIMP-1 in peritoneal fluid in patients with endometriosis.Materials/Methods: The study group consist of 23 patients with endometriosis who underwent laparoscopy. Stage I of endometriosis was diagnosed in 10 patients, stage II in 8 patients and 5 patients had stage III/IV of the disease. 12 patients with presence of benign non inflammatory adnexal tumor served as a reference group. Peritoneal fluid was stored until analysis at −700C. MMP-1, TIMP-1 and MMP-1/TIMP-1 complex were measured using ELISA (Amersham).Results: MMP-1 concentration was significantly higher (p < 0.05) in patients with endometriosis comparing to reference group: 3.75 vs 3.45 ng/ml. MMP-1 concentration was significantly higher in all stages of endometriosis in comparison to reference group. MMP-1 concentration was significantly higher (p < 0.05) in patients with stage III/IV of endometriosis in comparison to stage I and II of the disease. TIMP concentration was significantly higher (p < 0.05) in the reference group comparing to endometriotic patients: 218.75 vs 202.04 ng/ml. It is worth to notify that TIMP-1 was higher in patient with stage II and III of endometriosis in comparison to stage I of endometriosis. There was no difference in MMP-1/TIMP-1 concentration (p > 0.05) both between studied groups of patients 7.15 vs 5.98 ng/ml and among patients with endometriosis.Conclusions: Observed changes suggest that progression of the disease may differ depending on the stage of the disease. TIMP may be an important factor responsible for limiting the process of endometriosis. Better understanding the role of collagenolytic enzymes and its inhibitors may serve as background for the improvement of the classification and/or treatment of the disease.Supported By: None reported. Objectives: Many studies on endometriosis are focused on peritoneal fluid and immune cells regarding it the most frequent localization in peritoneal cavity. Immune cells potentially posses ability to produce matrix metalloproteinases (MMPs). MMPs belong to zinc dependent lytic enzymes that are responsible for degradation of collagen. This effect can enhance the process of implantation and progression of endometriosis. Tissue inhibitor of matrix metaloproteinase-1 (TIMP-1) is responsible for natural inactivation of MMP-1 by forming inactive complex MMP-1/TIMP-1. Design: In our study we measured MMP-1, TIMP-1 and its complex MMP-1/TIMP-1 in peritoneal fluid in patients with endometriosis. Materials/Methods: The study group consist of 23 patients with endometriosis who underwent laparoscopy. Stage I of endometriosis was diagnosed in 10 patients, stage II in 8 patients and 5 patients had stage III/IV of the disease. 12 patients with presence of benign non inflammatory adnexal tumor served as a reference group. Peritoneal fluid was stored until analysis at −700C. MMP-1, TIMP-1 and MMP-1/TIMP-1 complex were measured using ELISA (Amersham). Results: MMP-1 concentration was significantly higher (p < 0.05) in patients with endometriosis comparing to reference group: 3.75 vs 3.45 ng/ml. MMP-1 concentration was significantly higher in all stages of endometriosis in comparison to reference group. MMP-1 concentration was significantly higher (p < 0.05) in patients with stage III/IV of endometriosis in comparison to stage I and II of the disease. TIMP concentration was significantly higher (p < 0.05) in the reference group comparing to endometriotic patients: 218.75 vs 202.04 ng/ml. It is worth to notify that TIMP-1 was higher in patient with stage II and III of endometriosis in comparison to stage I of endometriosis. There was no difference in MMP-1/TIMP-1 concentration (p > 0.05) both between studied groups of patients 7.15 vs 5.98 ng/ml and among patients with endometriosis. Conclusions: Observed changes suggest that progression of the disease may differ depending on the stage of the disease. TIMP may be an important factor responsible for limiting the process of endometriosis. Better understanding the role of collagenolytic enzymes and its inhibitors may serve as background for the improvement of the classification and/or treatment of the disease. Supported By: None reported." @default.
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• W2043448022 date "2002-02-01" @default.
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• W2043448022 title "Concentration of matrix metalloproteinase-1, tissue inhibitor of matrix metalloproteinase-1 and its complex in peritoneal fluid in patients with endometriosis" @default.
• W2043448022 doi "https://doi.org/10.1016/s0015-0282(01)03162-4" @default.
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