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• W2043456488 abstract "HIV integrase (IN) catalyzes the insertion of proviral DNA into the host cell chromosome. While IN has strict sequence requirements for the viral cDNA ends, the integration site preference has been shown to be very diverse. Here, we mapped the HIV IN strand transfer reaction requirements using various short oligonucleotides (ON) that mimic the target DNA. Most double stranded DNA dodecamers served as excellent IN targets with variable integration efficiency depending mostly on the ON sequences. The preferred integration was lost with any changes in the geometry of the DNA double helical structures. Various hairpin-loop-forming ONs also served as efficient integration targets. Similar integration preferences were also observed for ONs, in which the nucleotide hairpin loop was replaced with a flexible aliphatic linker. The integration biases with all target DNA structures tested were significantly influenced by changes in the resulting secondary ON structures." @default.
• W2043456488 created "2016-06-24" @default.
• W2043456488 creator A5011509231 @default.
• W2043456488 creator A5021694243 @default.
• W2043456488 creator A5036463877 @default.
• W2043456488 creator A5090479609 @default.
• W2043456488 date "2009-08-01" @default.
• W2043456488 modified "2023-10-01" @default.
• W2043456488 title "Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides" @default.
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• W2043456488 doi "https://doi.org/10.1016/j.abb.2009.06.012" @default.
• W2043456488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19549503" @default.
• W2043456488 hasPublicationYear "2009" @default.
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