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• W2043476193 abstract "In the past two decades, hairy root research for the production of important secondary metabolites has received a lot of attention. The addition of knowledge to overcome the limiting culture parameters of the regulation of the metabolic pathway by specific molecules and the development of novel tools for metabolic engineering now offer new possibilities to improve the hairy root technique for the production of metabolites. Furthermore, engineering hairy roots for the production of animal proteins of therapeutic interest in confined and controlled in vitro conditions is seen as one of the exciting spin-offs of the technology. Recent progress made in the scale-up of the hairy root cultures has paved the way for industrial exploitation of this system. This review highlights some of the significant progress made in the past three years and discusses the potential implications of that research. In the past two decades, hairy root research for the production of important secondary metabolites has received a lot of attention. The addition of knowledge to overcome the limiting culture parameters of the regulation of the metabolic pathway by specific molecules and the development of novel tools for metabolic engineering now offer new possibilities to improve the hairy root technique for the production of metabolites. Furthermore, engineering hairy roots for the production of animal proteins of therapeutic interest in confined and controlled in vitro conditions is seen as one of the exciting spin-offs of the technology. Recent progress made in the scale-up of the hairy root cultures has paved the way for industrial exploitation of this system. This review highlights some of the significant progress made in the past three years and discusses the potential implications of that research. the medium is mixed and gassed by introducing air, or another gas mixture, inside a tube placed at the base of the reactor. an airlift system equipped with a concentric draft-tube internal-loop. Gas sparging is carried out on the draft-tube bottom so that the liquid circulation is driven from riser to down corner. a co-culture system with two identical glass domes separated by a silicon gasket. Cultures are immobilized inside the growth vessel by two stainless steel baskets that serve as mesh support. a system using cross-species culture growing in vitro in the same nutritive medium. a co-culture process achieved from two flasks with bottom side openings linked by silicon tubing. A hydrophilic synthetic membrane retains the plant cells in each flask but enabless medium exchange between both flasks. an efficient system for culturing plants or organs in vitro on inert substrates (sand, perlite, marble of clay) regularly irrigated by nutritive solutions. a sequestration and recovery process incorporating a resin or an organic phase, used to increase the production of metabolites and/or to avoid their degradation in the culture medium. production by transgenic plants of a wide diversity of recombinant molecules, such as drugs, antibodies, vaccines, enzymes or bioplastics, for medicinal, scientific or industrial purposes. a process that makes it possible to transfer the culture into a more commercially viable volume: from flasks to bioreactor. New types of bioreactors are designed for culturing the hairy roots, among which three systems are highlighted in the recent articles [34–36]. a powerful tool to induce dominant mutations into the plant genome after random insertion of a T-DNA construction that carries constitutive enhancer elements leading to overexpression of the flanking genes. This approach is used to discover new genes involved in the metabolite pathways." @default.
• W2043476193 created "2016-06-24" @default.
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• W2043476193 date "2006-09-01" @default.
• W2043476193 modified "2023-10-16" @default.
• W2043476193 title "Harnessing the potential of hairy roots: dawn of a new era" @default.
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• W2043476193 doi "https://doi.org/10.1016/j.tibtech.2006.07.002" @default.
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