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- W2043480400 abstract "A bstract : Relaxin stimulates cAMP production and activation of ERK and PI3K in THP‐1 cells. Relaxin also stimulates protein kinase C zeta (PKCζ) translocation to the plasma membrane in a PI3K‐dependent manner in THP‐1 and MCF‐7 cells. However, relaxin did not increase cAMP production in MCF‐7 cells. We overexpressed different adenylyl cyclase (AC) isoforms in MCF‐7 cells to examine coupling of endogenous relaxin receptors to cAMP production. Overexpression of types II and IV AC had no effect on cAMP production by relaxin. However, overexpression of type V AC, which is activated by PKCζ, showed synergistic stimulation of cAMP by relaxin and forskolin." @default.
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- W2043480400 date "2005-05-01" @default.
- W2043480400 modified "2023-09-27" @default.
- W2043480400 title "Relaxin Stimulates cAMP Production in MCF-7 Cells upon Overexpression of Type V Adenylyl Cyclase" @default.
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- W2043480400 doi "https://doi.org/10.1196/annals.1282.044" @default.
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