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- W2043482921 abstract "The advantages of oral insulin are well-recognized, yet such formulations are still unavailable. Towards that goal we developed, and evaluated in diabetic ICR mice , two novel insulin microparticles for oral delivery. Although different in structure and shape, both microparticle formulations share: (i) hyaluronan on their surface (ii) fibrillar insulin, loaded at 50–100% efficiency over the insulin range of 1–10 mg/ml and (iii) high retention of insulin loads in simulated gastro-intestinal environments. BGL values in diabetic ICR mice were tested over a time span of 8 h, following a single oral dose of each formulation, using two protocols: the conventional (12 h pre-fasting and 8 h fasting); our revised protocol (no pre-fasting, meal at t = 4 h). In both protocols, initial blood glucose levels (BGL) were 400–600 mg/dL and the novel formulations generated a continuous reduction of BGL. Results in the revised protocol, that mimics human eating habits, were more pronounced, providing stable (over several hours) glucose reductions approaching non-diabetic BGL values. These two fibrillar insulin formulations, and the fibrillar form for therapeutic proteins, merit further studies." @default.
- W2043482921 created "2016-06-24" @default.
- W2043482921 creator A5071606583 @default.
- W2043482921 creator A5083995181 @default.
- W2043482921 creator A5090761366 @default.
- W2043482921 date "2010-04-02" @default.
- W2043482921 modified "2023-09-24" @default.
- W2043482921 title "Novel fibrillar insulin formulations for oral administration: Formulation and in vivo studies in diabetic mice" @default.
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- W2043482921 doi "https://doi.org/10.1016/j.jconrel.2009.12.018" @default.
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