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- W2043489809 abstract "Capsaicin exerts both excitatory and desensitizing effects on a subset of sensory neurons during development in the dorsal root ganglion, but it is not known how widespread these effects are in other sensory ganglia especially those not known to have any pain sensitivity. The capsaicin sensitivity of auditory neurons in the spiral ganglion was investigated in acute preparations from three postnatal age groups in the hamster: postnatal days 6-8 (group 1), postnatal days 13-15 (group 2) and postnatal days 20-22 (group 3). Morphologically, capsaicin altered the shape, size, and staining characteristics of spiral ganglion cells (SGCs) across all age groups and this effect was apparently not selective for any identifiable subpopulation. However, SGCs from the youngest age groups were particularly sensitive to capsaicin neurotoxicity. When incubated in media that contained cobalt, capsaicin stimulated cobalt uptake within SGCs. KCl depolarization was able to produce the same level of cobalt uptake as capsaicin treatment. Our data suggest that the extent of capsaicin neurotoxicity in the spiral ganglion is strongly age dependent, involves the entry of calcium ions and is relatively nonspecific." @default.
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- W2043489809 date "1994-08-01" @default.
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- W2043489809 title "Acute effects of capsaicin on the postnatal spiral ganglion" @default.
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- W2043489809 doi "https://doi.org/10.1016/0736-5748(94)90036-1" @default.
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