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- W2043502308 endingPage "1626" @default.
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- W2043502308 abstract "Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEAD227A exclusively binds with its N-terminal domain to the α chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy." @default.
- W2043502308 created "2016-06-24" @default.
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- W2043502308 creator A5035822127 @default.
- W2043502308 creator A5047379462 @default.
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- W2043502308 date "2002-12-01" @default.
- W2043502308 modified "2023-09-27" @default.
- W2043502308 title "Crystal Structure of a SEA Variant in Complex with MHC Class II Reveals the Ability of SEA to Crosslink MHC Molecules" @default.
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- W2043502308 doi "https://doi.org/10.1016/s0969-2126(02)00895-x" @default.
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