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• W2043503241 abstract "A series of pyridazines were prepared and evaluated for their anti-HIV activity. The new synthetic route involving a novel rearrangement reaction provided a practical method for the preparation of 5-hydroxypyridazines. The primary bioassay results indicated that most of the pyridazines possess anti-HIV activity. It ought to been mentioned that the rearranged compounds 35 and 39 exhibited relatively higher HIV inhibitory effect. Most of the synthesized compounds were also found to possess good anti-TMV activity, of which compound 9 showed similar in vivo anti-TMV activity to commercial plant virucide Ribavirin. This work provides a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration and optimization of previously reported antiviral agents." @default.
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• W2043503241 date "2012-08-01" @default.
• W2043503241 modified "2023-10-10" @default.
• W2043503241 title "Design, synthesis and antiviral activity of novel pyridazines" @default.
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• W2043503241 doi "https://doi.org/10.1016/j.ejmech.2012.04.020" @default.
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