FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043524166> ?p ?o ?g. }

• W2043524166 endingPage "1666" @default.
• W2043524166 startingPage "1659" @default.
• W2043524166 abstract "Local delivery of antimicrobial agents in inflamed periodontal pocket has been shown to be effective in reducing periodontopathic microorganisms. This research focuses on developing and characterizing bioerodible formulations based on auto-catalyzed poly(ortho esters) (POExLAy) for modulated release of tetracycline over 2 weeks. POExLAy are a new versatile family of POE-containing lactoyl lactyl dimers in the polymer backbone. By modifying the proportion of lactic acid in the polymer, viscous or solid materials having different degradation rate can be produced. The formulations can be either injected or placed as a solid device directly into the periodontal pocket. Tetracycline-free base incorporated into these materials was released within 10-14 days depending on polymer structure. Increase in lactic acid content in the polymer tended to increase the drug release rate and to reduce the initial lag time. Tetracycline release from such bioerodible delivery system occurs predominantly by surface erosion of the polymeric matrix, leading to kinetics which can be zero order. This periodontal drug delivery system is designed to be used as an adjunct in the treatment of periodontal diseases. Clinical studies are currently in progress." @default.
• W2043524166 created "2016-06-24" @default.
• W2043524166 creator A5010456027 @default.
• W2043524166 creator A5013683035 @default.
• W2043524166 creator A5024901508 @default.
• W2043524166 creator A5025317199 @default.
• W2043524166 creator A5063852930 @default.
• W2043524166 date "2001-06-01" @default.
• W2043524166 modified "2023-09-27" @default.
• W2043524166 title "Optimization of a novel bioerodible device based on auto-catalyzed poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket" @default.
• W2043524166 cites W1864209824 @default.
• W2043524166 cites W1966385208 @default.
• W2043524166 cites W1966986035 @default.
• W2043524166 cites W1979842542 @default.
• W2043524166 cites W1981722417 @default.
• W2043524166 cites W1985791736 @default.
• W2043524166 cites W1998799311 @default.
• W2043524166 cites W2000122321 @default.
• W2043524166 cites W2005086892 @default.
• W2043524166 cites W201622343 @default.
• W2043524166 cites W2018667218 @default.
• W2043524166 cites W2022158598 @default.
• W2043524166 cites W2028499573 @default.
• W2043524166 cites W2037254545 @default.
• W2043524166 cites W2045618040 @default.
• W2043524166 cites W2053183856 @default.
• W2043524166 cites W2065152600 @default.
• W2043524166 cites W2069973999 @default.
• W2043524166 cites W2074932456 @default.
• W2043524166 cites W2078395916 @default.
• W2043524166 cites W2083059267 @default.
• W2043524166 cites W2087175706 @default.
• W2043524166 cites W2094064844 @default.
• W2043524166 cites W2104381799 @default.
• W2043524166 cites W2140732960 @default.
• W2043524166 cites W2169437932 @default.
• W2043524166 cites W2416660217 @default.
• W2043524166 doi "https://doi.org/10.1016/s0142-9612(00)00327-6" @default.
• W2043524166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11374468" @default.
• W2043524166 hasPublicationYear "2001" @default.
• W2043524166 type Work @default.
• W2043524166 sameAs 2043524166 @default.
• W2043524166 citedByCount "34" @default.
• W2043524166 countsByYear W20435241662012 @default.
• W2043524166 countsByYear W20435241662013 @default.
• W2043524166 countsByYear W20435241662014 @default.
• W2043524166 countsByYear W20435241662015 @default.
• W2043524166 countsByYear W20435241662016 @default.
• W2043524166 countsByYear W20435241662017 @default.
• W2043524166 countsByYear W20435241662020 @default.
• W2043524166 countsByYear W20435241662022 @default.
• W2043524166 crossrefType "journal-article" @default.
• W2043524166 hasAuthorship W2043524166A5010456027 @default.
• W2043524166 hasAuthorship W2043524166A5013683035 @default.
• W2043524166 hasAuthorship W2043524166A5024901508 @default.
• W2043524166 hasAuthorship W2043524166A5025317199 @default.
• W2043524166 hasAuthorship W2043524166A5063852930 @default.
• W2043524166 hasConcept C121332964 @default.
• W2043524166 hasConcept C136229726 @default.
• W2043524166 hasConcept C13965031 @default.
• W2043524166 hasConcept C148898269 @default.
• W2043524166 hasConcept C159985019 @default.
• W2043524166 hasConcept C161790260 @default.
• W2043524166 hasConcept C171250308 @default.
• W2043524166 hasConcept C178790620 @default.
• W2043524166 hasConcept C185592680 @default.
• W2043524166 hasConcept C192562407 @default.
• W2043524166 hasConcept C21951064 @default.
• W2043524166 hasConcept C2775920511 @default.
• W2043524166 hasConcept C2779820397 @default.
• W2043524166 hasConcept C2780923616 @default.
• W2043524166 hasConcept C501593827 @default.
• W2043524166 hasConcept C521977710 @default.
• W2043524166 hasConcept C523546767 @default.
• W2043524166 hasConcept C54355233 @default.
• W2043524166 hasConcept C55493867 @default.
• W2043524166 hasConcept C62520636 @default.
• W2043524166 hasConcept C71924100 @default.
• W2043524166 hasConcept C86803240 @default.
• W2043524166 hasConceptScore W2043524166C121332964 @default.
• W2043524166 hasConceptScore W2043524166C136229726 @default.
• W2043524166 hasConceptScore W2043524166C13965031 @default.
• W2043524166 hasConceptScore W2043524166C148898269 @default.
• W2043524166 hasConceptScore W2043524166C159985019 @default.
• W2043524166 hasConceptScore W2043524166C161790260 @default.
• W2043524166 hasConceptScore W2043524166C171250308 @default.
• W2043524166 hasConceptScore W2043524166C178790620 @default.
• W2043524166 hasConceptScore W2043524166C185592680 @default.
• W2043524166 hasConceptScore W2043524166C192562407 @default.
• W2043524166 hasConceptScore W2043524166C21951064 @default.
• W2043524166 hasConceptScore W2043524166C2775920511 @default.
• W2043524166 hasConceptScore W2043524166C2779820397 @default.
• W2043524166 hasConceptScore W2043524166C2780923616 @default.
• W2043524166 hasConceptScore W2043524166C501593827 @default.
• W2043524166 hasConceptScore W2043524166C521977710 @default.
• W2043524166 hasConceptScore W2043524166C523546767 @default.
• W2043524166 hasConceptScore W2043524166C54355233 @default.
• W2043524166 hasConceptScore W2043524166C55493867 @default.

• next