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• W2043549287 endingPage "204" @default.
• W2043549287 startingPage "192" @default.
• W2043549287 abstract "Abstract Cis – trans isomerization of amide bonds plays critical roles in protein molecular recognition, protein folding, protein misfolding, and disease. Aromatic–proline sequences are particularly prone to exhibit cis amide bonds. The roles of residues adjacent to a tyrosine–proline residue pair on cis – trans isomerism were examined. A short series of peptides XYPZ was synthesized and cis – trans isomerism was analyzed. Based on these initial studies, a series of peptides XYPN, X = all 20 canonical amino acids, was synthesized and analyzed by NMR for i residue effects on cis – trans isomerization. The following effects were observed: (a) aromatic residues immediately preceding Tyr–Pro disfavor cis amide bonds, with K trans/cis = 5.7–8.0, W > Y > F ; (b) proline residues preceding Tyr–Pro lead to multiple species, exhibiting cis – trans isomerization of either or both X–Pro amide bonds; and (c) other residues exhibit similar values of K trans/cis (= 2.9–4.2), with Thr and protonated His exhibiting the highest fraction cis . β‐Branched and short polar residues were somewhat more favorable in stabilizing the cis conformation. Phosphorylation of serine at the i position modestly increases the stability of the cis conformer. In addition, the effect of the i +3 residue was examined in a limited series of peptides TYPZ. NMR data indicated that aromatic residues, Pro, Asn, Ala, and Val at the i +3 residue all favor cis amide bonds, with aromatic residues and Asn favoring more compact ϕ at Tyr cis and Ala and Pro favoring more extended ϕ at Tyr cis . D ‐Alanine at the i +3 position particularly disfavors cis amide bonds. © 2005 Wiley Periodicals, Inc. Biopolymers 84: 192–204, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com" @default.
• W2043549287 created "2016-06-24" @default.
• W2043549287 creator A5006409637 @default.
• W2043549287 creator A5038816965 @default.
• W2043549287 creator A5056376458 @default.
• W2043549287 creator A5072255412 @default.
• W2043549287 date "2005-10-06" @default.
• W2043549287 modified "2023-10-17" @default.
• W2043549287 title "Effects ofi andi+3 residue identity onCis–Trans isomerism of the aromatici+1–prolyli+2 amide bond: Implications for type VI β-turn formation" @default.
• W2043549287 cites W1499340096 @default.
• W2043549287 cites W1544623810 @default.
• W2043549287 cites W1586022877 @default.
• W2043549287 cites W1603646817 @default.
• W2043549287 cites W1966479792 @default.
• W2043549287 cites W1968983628 @default.
• W2043549287 cites W1969360729 @default.
• W2043549287 cites W1971186656 @default.
• W2043549287 cites W1971763423 @default.
• W2043549287 cites W1971892655 @default.
• W2043549287 cites W1973981331 @default.
• W2043549287 cites W1974698351 @default.
• W2043549287 cites W1975157054 @default.
• W2043549287 cites W1978107630 @default.
• W2043549287 cites W1978162314 @default.
• W2043549287 cites W1978713271 @default.
• W2043549287 cites W1978892474 @default.
• W2043549287 cites W1979272734 @default.
• W2043549287 cites W1979310770 @default.
• W2043549287 cites W1979991584 @default.
• W2043549287 cites W1980440450 @default.
• W2043549287 cites W1981001176 @default.
• W2043549287 cites W1981729255 @default.
• W2043549287 cites W1981946193 @default.
• W2043549287 cites W1982523250 @default.
• W2043549287 cites W1984816958 @default.
• W2043549287 cites W1986751830 @default.
• W2043549287 cites W1988909256 @default.
• W2043549287 cites W1992001226 @default.
• W2043549287 cites W1992095999 @default.
• W2043549287 cites W1995508496 @default.
• W2043549287 cites W1997320716 @default.
• W2043549287 cites W1999064211 @default.
• W2043549287 cites W1999548431 @default.
• W2043549287 cites W2000430596 @default.
• W2043549287 cites W2000572678 @default.
• W2043549287 cites W2003273922 @default.
• W2043549287 cites W2006421916 @default.
• W2043549287 cites W2008012729 @default.
• W2043549287 cites W2008156250 @default.
• W2043549287 cites W2008357770 @default.
• W2043549287 cites W2009312115 @default.
• W2043549287 cites W2010690008 @default.
• W2043549287 cites W2011926767 @default.
• W2043549287 cites W2017639307 @default.
• W2043549287 cites W2017982914 @default.
• W2043549287 cites W2018691822 @default.
• W2043549287 cites W2018937595 @default.
• W2043549287 cites W2020734433 @default.
• W2043549287 cites W2021436012 @default.
• W2043549287 cites W2021926647 @default.
• W2043549287 cites W2022235170 @default.
• W2043549287 cites W2025312920 @default.
• W2043549287 cites W2025935196 @default.
• W2043549287 cites W2026346256 @default.
• W2043549287 cites W2028514027 @default.
• W2043549287 cites W2029277542 @default.
• W2043549287 cites W2031627742 @default.
• W2043549287 cites W2038082991 @default.
• W2043549287 cites W2039694363 @default.
• W2043549287 cites W2045101022 @default.
• W2043549287 cites W2047572594 @default.
• W2043549287 cites W2048631643 @default.
• W2043549287 cites W2049064910 @default.
• W2043549287 cites W2049107280 @default.
• W2043549287 cites W2050023137 @default.
• W2043549287 cites W2050178436 @default.
• W2043549287 cites W2050197018 @default.
• W2043549287 cites W2052034167 @default.
• W2043549287 cites W2052618695 @default.
• W2043549287 cites W2053721311 @default.
• W2043549287 cites W2056852982 @default.
• W2043549287 cites W2057451487 @default.
• W2043549287 cites W2058967610 @default.
• W2043549287 cites W2059455290 @default.
• W2043549287 cites W2059523269 @default.
• W2043549287 cites W2061144516 @default.
• W2043549287 cites W2062714484 @default.
• W2043549287 cites W2064144150 @default.
• W2043549287 cites W2067055371 @default.
• W2043549287 cites W2068348235 @default.
• W2043549287 cites W2070085790 @default.
• W2043549287 cites W2070412797 @default.
• W2043549287 cites W2071075259 @default.
• W2043549287 cites W2071474710 @default.
• W2043549287 cites W2074655761 @default.
• W2043549287 cites W2074808135 @default.
• W2043549287 cites W2075320676 @default.
• W2043549287 cites W2077456115 @default.

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