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• W2043567356 abstract "Treatment with bismuth-containing remedies has been long associated with the alleviation of minor gastric ailments. Bismuth salts have a potent antimicrobial activity, and are part of the current standard regime used to treat Helicobacter pylori infection. H. pylori is considered to be the major etiological factor in the development of peptic ulcer disease. Earlier efficacious treatments for peptic ulcer included the oral administration of Tween detergents. We have found that these agents have an inhibitory effect on H. pylori adhesion to the lipid species phosphatidylethanolamine (PE) and gangliotetraosylceramide (Gg4) shown previously to be receptors for H. pylori binding in vitro. H. pylori binding to PE and Gg4 was inhibited after a thirty minute preincubation with different bismuth compounds: bismuth subsalicylate > bismuth subgallate > bismuth carbonate > colloidal bismuth subcitrate > tripotassium dicitrato bismuthate. No inhibitory effect on H. pylori binding was observed when bismuth salts were added directly into the binding assay. No changes in bacterial morphology and motility were observed after the thirty minute incubation. Pretreatment with Tween detergents also inhibited H. pylori receptor binding by up to 80% at concentrations as low as 0.0001%. These results suggest that inhibition of H. pylori / host cell adhesion might play a role in efficacious treatment for this infection. Wismuthaltige Präparate dienen seit langem zur Linderung geringgradiger Magenbeschwerden. Wismutsalze haben eine starke antimikrobielle Wirkung, and sie sind Teil der Standardbehandlung von Infektionen mit Helicobacter pylori. H. pylori wird als der hauptsächliche ätiologische Faktor bei der Entwicklung von Magengeschwüren angesehen. Zu den fruher verwendeten wirksamen Therapien des Magengeschwurs zählt die orale Gabe von Tween-Tensiden. Wir haben festgestellt, daß these Mittel die Adhäsion von H. pylori an die Lipide Phosphatidylethanolamin (PE) and Gangliotetraosylceramid (Gg4) hemmen, die bereits früher als Rezeptoren für die in-vitro-Bindung von H. pylori nachgewiesen wurden. Die Bindung von H. pylori an PE and Gg4 wurde nach 30 min Vorinkubation mit verschiedenen Wismutverbindungen (Wismutsubsalicylat > Wismutsubgallat > Wismutcarbonat > kolloidales Wismutsubcitrat > Trikalium-Dicitratwismutat) gehemmt. Bei direkter Zugabe der Wismutsalze in den Bindungstest wurde keine Hemmwirkung auf H. pylori festgestellt. Nach 30 min Inkubation wurden keine Veränderungen der bakteriellen Morphologie and Motilität beobachtet. Eine Vorbehandlung mit Tween-Tensiden hemmte ebenfalls die Rezeptorbindung von H. pylori bis zu 80% in niedrigen Konzentrationen ab 0.0001%. Diese Ergebnisse deuten an, daß eine Hemmung der Adhäsion von H. pylori an die Wirtszelle bei der wirksamen Behandlung der Infektion durch diesen Erreger eine Rolle spielen könnte." @default.
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• W2043567356 date "1993-09-01" @default.
• W2043567356 modified "2023-09-29" @default.
• W2043567356 title "Therapeutics used to alleviate peptic ulcers inhibit H. pylori receptor binding in vitro" @default.
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• W2043567356 doi "https://doi.org/10.1016/s0934-8840(11)80962-x" @default.
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