Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043575440> ?p ?o ?g. }
- W2043575440 endingPage "218" @default.
- W2043575440 startingPage "205" @default.
- W2043575440 abstract "Osteoarthritis and rheumatoid arthritis are rheumatic diseases for which a curative treatment does not currently exist. Their management is directed towards pain relief achieved with different classes of drugs among which non-steroidal and steroidal anti-inflammatory substances are the most frequently used agents. Nevertheless, the oral or systemic administration of such drugs is hindered by numerous side effects, which could be overcome by their intra-articular (i-a.) administration as dosage forms capable of gradually releasing the active substance. The present review article summarises the research done in the field of drug delivery systems for i-a. injection vs. current management of osteoarthritis or rheumatoid arthritis. Aspects such as the influence of size, shape, polymer matrix or targeted drug on the i-a. retention time, phagocytosis and biological activity will be discussed. Finally, we will comment on the need for adapted delivery systems for the novel and very potent anti-inflammatory drugs, such as inhibitors of the p38 mitogen-activated protein kinase or the IL-1β conversion enzyme, which to date cannot be properly used due to the severe side effects associated with their systemic administration." @default.
- W2043575440 created "2016-06-24" @default.
- W2043575440 creator A5048496252 @default.
- W2043575440 creator A5049777995 @default.
- W2043575440 creator A5057222873 @default.
- W2043575440 date "2009-10-01" @default.
- W2043575440 modified "2023-09-23" @default.
- W2043575440 title "Intra-articular drug delivery systems for the treatment of rheumatic diseases: A review of the factors influencing their performance" @default.
- W2043575440 cites W122501809 @default.
- W2043575440 cites W1495782459 @default.
- W2043575440 cites W1501675811 @default.
- W2043575440 cites W1518457776 @default.
- W2043575440 cites W1533808086 @default.
- W2043575440 cites W1541137078 @default.
- W2043575440 cites W1590542171 @default.
- W2043575440 cites W1604024841 @default.
- W2043575440 cites W163534134 @default.
- W2043575440 cites W1769084132 @default.
- W2043575440 cites W1800668800 @default.
- W2043575440 cites W182195150 @default.
- W2043575440 cites W1861857793 @default.
- W2043575440 cites W1888297563 @default.
- W2043575440 cites W19153813 @default.
- W2043575440 cites W1921708445 @default.
- W2043575440 cites W1946243298 @default.
- W2043575440 cites W1964706296 @default.
- W2043575440 cites W1965435354 @default.
- W2043575440 cites W1968937965 @default.
- W2043575440 cites W1970662652 @default.
- W2043575440 cites W1972001109 @default.
- W2043575440 cites W1972958157 @default.
- W2043575440 cites W1973232910 @default.
- W2043575440 cites W1975916494 @default.
- W2043575440 cites W1976588021 @default.
- W2043575440 cites W1980246074 @default.
- W2043575440 cites W1980751958 @default.
- W2043575440 cites W1984026160 @default.
- W2043575440 cites W1984367241 @default.
- W2043575440 cites W1987078254 @default.
- W2043575440 cites W1990004505 @default.
- W2043575440 cites W1990648762 @default.
- W2043575440 cites W1990994167 @default.
- W2043575440 cites W1993287280 @default.
- W2043575440 cites W1994723172 @default.
- W2043575440 cites W1997390819 @default.
- W2043575440 cites W1998787995 @default.
- W2043575440 cites W2001186853 @default.
- W2043575440 cites W2002164057 @default.
- W2043575440 cites W2002387722 @default.
- W2043575440 cites W2002884676 @default.
- W2043575440 cites W2005091462 @default.
- W2043575440 cites W2007229660 @default.
- W2043575440 cites W2009383149 @default.
- W2043575440 cites W2010610984 @default.
- W2043575440 cites W2011487877 @default.
- W2043575440 cites W2012091362 @default.
- W2043575440 cites W2015227877 @default.
- W2043575440 cites W2016189767 @default.
- W2043575440 cites W2017638669 @default.
- W2043575440 cites W2019598869 @default.
- W2043575440 cites W2021367421 @default.
- W2043575440 cites W2022284349 @default.
- W2043575440 cites W2024785463 @default.
- W2043575440 cites W2025016174 @default.
- W2043575440 cites W2025881245 @default.
- W2043575440 cites W2026865649 @default.
- W2043575440 cites W2028419892 @default.
- W2043575440 cites W2032777234 @default.
- W2043575440 cites W2033121188 @default.
- W2043575440 cites W2034910498 @default.
- W2043575440 cites W2038886248 @default.
- W2043575440 cites W2039269508 @default.
- W2043575440 cites W2039543011 @default.
- W2043575440 cites W2042800059 @default.
- W2043575440 cites W2043208950 @default.
- W2043575440 cites W2049521062 @default.
- W2043575440 cites W2050288383 @default.
- W2043575440 cites W2052425219 @default.
- W2043575440 cites W2053449083 @default.
- W2043575440 cites W2058451148 @default.
- W2043575440 cites W2059445322 @default.
- W2043575440 cites W2060536308 @default.
- W2043575440 cites W2062247132 @default.
- W2043575440 cites W2063434844 @default.
- W2043575440 cites W2064325544 @default.
- W2043575440 cites W2065104971 @default.
- W2043575440 cites W2065575328 @default.
- W2043575440 cites W2072167574 @default.
- W2043575440 cites W2073364457 @default.
- W2043575440 cites W2073647809 @default.
- W2043575440 cites W2074254498 @default.
- W2043575440 cites W2074755279 @default.
- W2043575440 cites W2078828283 @default.
- W2043575440 cites W2078927247 @default.
- W2043575440 cites W2079617573 @default.
- W2043575440 cites W2082489665 @default.
- W2043575440 cites W2083284361 @default.
- W2043575440 cites W2085140907 @default.