FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043590202> ?p ?o ?g. }

• W2043590202 endingPage "792" @default.
• W2043590202 startingPage "785" @default.
• W2043590202 abstract "Introduction Laboratory experiments indicate that the nitric oxide erectile pathway is testosterone‐dependent. Castration induces erectile dysfunction (ED) and reduction in nitric oxide synthase and in phosphodiesterase type 5 (PDE5) in the erectile tissue. Furthermore, castration causes apoptosis adversely affecting smooth muscle content and penile hemodynamics leading to veno‐occlusive dysfunction. Testosterone therapy reverses these structural, biochemical, and physiological changes. In humans, testosterone therapy improves erectile function in men with hypogonadism. However, the efficacy of testosterone monotherapy may not be adequate because of the multifactorial nature of the pathophysiology of ED. Methods Preliminary data from a number of studies have been reviewed. Results There are emerging evidence‐based benefits to using the combination of testoterone and PDE5 inhibitors. A recently published multicenter, randomized, placebo‐controlled study evaluated the safety and efficacy of testosterone gel 1% plus sildenafil vs. placebo gel plus sildenafil, in producing an erectile response in hypogonadal men who had failed prior sildenafil alone for ED. Screening yielded a prevalence of hypogonadism in ED patients who failed prior sildenafil. Following randomization, the double‐blinded treatment phase was 12 weeks. Testosterone therapy with testosterone gel significantly improved erectile function in response to sildenafil. In addition, it significantly improved orgasmic function and patient satisfaction. Conclusion It is important to screen all men with ED for hypogonadism, especially those with a history of inadequate response to prior PDE5 inhibitors. The combination of testosterone plus PDE5 inhibitors may be considered for the treatment of ED in men with low to low–normal testosterone levels, who had inadequate response to prior treatment with PDE5 inhibitors alone. Shabsigh R. Testosterone therapy in erectile dysfunction and hypogonadism. J Sex Med 2005;2:785–792." @default.
• W2043590202 created "2016-06-24" @default.
• W2043590202 creator A5025657947 @default.
• W2043590202 date "2005-11-01" @default.
• W2043590202 modified "2023-09-27" @default.
• W2043590202 title "Testosterone Therapy in Erectile Dysfunction and Hypogonadism" @default.
• W2043590202 cites W105499144 @default.
• W2043590202 cites W1562814494 @default.
• W2043590202 cites W1590654957 @default.
• W2043590202 cites W1718442556 @default.
• W2043590202 cites W1965096414 @default.
• W2043590202 cites W1967721674 @default.
• W2043590202 cites W1969811041 @default.
• W2043590202 cites W1979474986 @default.
• W2043590202 cites W1994273184 @default.
• W2043590202 cites W1999033981 @default.
• W2043590202 cites W2001610421 @default.
• W2043590202 cites W2004935016 @default.
• W2043590202 cites W2013360023 @default.
• W2043590202 cites W2015383498 @default.
• W2043590202 cites W2016779560 @default.
• W2043590202 cites W2025162207 @default.
• W2043590202 cites W2028785525 @default.
• W2043590202 cites W2028963576 @default.
• W2043590202 cites W2031328038 @default.
• W2043590202 cites W2032560652 @default.
• W2043590202 cites W2040829454 @default.
• W2043590202 cites W2046656172 @default.
• W2043590202 cites W2047864194 @default.
• W2043590202 cites W2060927118 @default.
• W2043590202 cites W2066182489 @default.
• W2043590202 cites W2078753971 @default.
• W2043590202 cites W2083804778 @default.
• W2043590202 cites W2086093979 @default.
• W2043590202 cites W2109596022 @default.
• W2043590202 cites W2112945186 @default.
• W2043590202 cites W2115448142 @default.
• W2043590202 cites W2121881032 @default.
• W2043590202 cites W2122279042 @default.
• W2043590202 cites W2125818234 @default.
• W2043590202 cites W2127205244 @default.
• W2043590202 cites W2128158698 @default.
• W2043590202 cites W2142623609 @default.
• W2043590202 cites W2153768594 @default.
• W2043590202 cites W2161417745 @default.
• W2043590202 cites W2162689023 @default.
• W2043590202 cites W2297358297 @default.
• W2043590202 cites W2325505624 @default.
• W2043590202 cites W4243770305 @default.
• W2043590202 cites W4256438740 @default.
• W2043590202 doi "https://doi.org/10.1111/j.1743-6109.2005.00139.x" @default.
• W2043590202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16422803" @default.
• W2043590202 hasPublicationYear "2005" @default.
• W2043590202 type Work @default.
• W2043590202 sameAs 2043590202 @default.
• W2043590202 citedByCount "71" @default.
• W2043590202 countsByYear W20435902022012 @default.
• W2043590202 countsByYear W20435902022013 @default.
• W2043590202 countsByYear W20435902022014 @default.
• W2043590202 countsByYear W20435902022016 @default.
• W2043590202 countsByYear W20435902022017 @default.
• W2043590202 countsByYear W20435902022018 @default.
• W2043590202 countsByYear W20435902022020 @default.
• W2043590202 countsByYear W20435902022021 @default.
• W2043590202 countsByYear W20435902022022 @default.
• W2043590202 countsByYear W20435902022023 @default.
• W2043590202 crossrefType "journal-article" @default.
• W2043590202 hasAuthorship W2043590202A5025657947 @default.
• W2043590202 hasConcept C126322002 @default.
• W2043590202 hasConcept C126894567 @default.
• W2043590202 hasConcept C134018914 @default.
• W2043590202 hasConcept C142724271 @default.
• W2043590202 hasConcept C204787440 @default.
• W2043590202 hasConcept C27081682 @default.
• W2043590202 hasConcept C2776768464 @default.
• W2043590202 hasConcept C2779279991 @default.
• W2043590202 hasConcept C2779929075 @default.
• W2043590202 hasConcept C71924100 @default.
• W2043590202 hasConcept C74534348 @default.
• W2043590202 hasConceptScore W2043590202C126322002 @default.
• W2043590202 hasConceptScore W2043590202C126894567 @default.
• W2043590202 hasConceptScore W2043590202C134018914 @default.
• W2043590202 hasConceptScore W2043590202C142724271 @default.
• W2043590202 hasConceptScore W2043590202C204787440 @default.
• W2043590202 hasConceptScore W2043590202C27081682 @default.
• W2043590202 hasConceptScore W2043590202C2776768464 @default.
• W2043590202 hasConceptScore W2043590202C2779279991 @default.
• W2043590202 hasConceptScore W2043590202C2779929075 @default.
• W2043590202 hasConceptScore W2043590202C71924100 @default.
• W2043590202 hasConceptScore W2043590202C74534348 @default.
• W2043590202 hasIssue "6" @default.
• W2043590202 hasLocation W20435902021 @default.
• W2043590202 hasLocation W20435902022 @default.
• W2043590202 hasOpenAccess W2043590202 @default.
• W2043590202 hasPrimaryLocation W20435902021 @default.
• W2043590202 hasRelatedWork W1757546955 @default.
• W2043590202 hasRelatedWork W1992414199 @default.
• W2043590202 hasRelatedWork W2019666885 @default.

• next