FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043601731> ?p ?o ?g. }

• W2043601731 endingPage "1517" @default.
• W2043601731 startingPage "1506" @default.
• W2043601731 abstract "We aim to define the role of Kupffer cells in intrahepatic antigen presentation, using the selective delivery of antigen to Kupffer cells rather than other populations of liver antigen-presenting cells. To achieve this we developed a novel antigen delivery system that can target antigens to macrophages, based on a galactosylated low-density lipoprotein nanoscale platform. Antigen was delivered via the galactose particle receptor (GPr), internalized, degraded and presented to T cells. The conjugation of fluoresceinated ovalbumin (FLUO-OVA) and lactobionic acid with LDL resulted in a substantially increased uptake of FLUO-OVA by murine macrophage-like ANA1 cells in preference to NIH3T3 cells, and by primary peritoneal macrophages in preference to primary hepatic stellate cells. Such preferential uptake led to enhanced proliferation of OVA specific T cells, showing that the galactosylated LDL nanoscale platform is a successful antigen carrier, targeting antigen to macrophages but not to all categories of antigen presenting cells. This system will allow targeted delivery of antigen to macrophages in the liver and elsewhere, addressing the question of the role of Kupffer cells in liver immunology. It may also be an effective way of delivering drugs or vaccines directly at macrophages." @default.
• W2043601731 created "2016-06-24" @default.
• W2043601731 creator A5018427690 @default.
• W2043601731 creator A5046570644 @default.
• W2043601731 creator A5049721969 @default.
• W2043601731 creator A5081866388 @default.
• W2043601731 creator A5085169432 @default.
• W2043601731 date "2009-08-10" @default.
• W2043601731 modified "2023-09-25" @default.
• W2043601731 title "Galactosylated LDL Nanoparticles: A Novel Targeting Delivery System To Deliver Antigen to Macrophages and Enhance Antigen Specific T Cell Responses" @default.
• W2043601731 cites W1481001557 @default.
• W2043601731 cites W1608216976 @default.
• W2043601731 cites W1982968590 @default.
• W2043601731 cites W1985658879 @default.
• W2043601731 cites W1990985604 @default.
• W2043601731 cites W1992262718 @default.
• W2043601731 cites W1996446216 @default.
• W2043601731 cites W1997408488 @default.
• W2043601731 cites W2004229205 @default.
• W2043601731 cites W2005348794 @default.
• W2043601731 cites W2011344306 @default.
• W2043601731 cites W2018085133 @default.
• W2043601731 cites W2019592377 @default.
• W2043601731 cites W2020167947 @default.
• W2043601731 cites W2021122139 @default.
• W2043601731 cites W2024470960 @default.
• W2043601731 cites W2028992070 @default.
• W2043601731 cites W2029741187 @default.
• W2043601731 cites W2030898714 @default.
• W2043601731 cites W2031185391 @default.
• W2043601731 cites W2037555606 @default.
• W2043601731 cites W2042955938 @default.
• W2043601731 cites W2043046278 @default.
• W2043601731 cites W2045956714 @default.
• W2043601731 cites W2046608900 @default.
• W2043601731 cites W2047908014 @default.
• W2043601731 cites W2049024486 @default.
• W2043601731 cites W2049451246 @default.
• W2043601731 cites W2053566310 @default.
• W2043601731 cites W2058453102 @default.
• W2043601731 cites W2065790541 @default.
• W2043601731 cites W2068865004 @default.
• W2043601731 cites W2074724011 @default.
• W2043601731 cites W2079439306 @default.
• W2043601731 cites W2079983241 @default.
• W2043601731 cites W2082170878 @default.
• W2043601731 cites W2082221090 @default.
• W2043601731 cites W2086451443 @default.
• W2043601731 cites W2093100047 @default.
• W2043601731 cites W2095393642 @default.
• W2043601731 cites W2113078714 @default.
• W2043601731 cites W2123461995 @default.
• W2043601731 cites W2126793509 @default.
• W2043601731 cites W2148357165 @default.
• W2043601731 cites W2164395089 @default.
• W2043601731 cites W2402457099 @default.
• W2043601731 doi "https://doi.org/10.1021/mp900081y" @default.
• W2043601731 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2782853" @default.
• W2043601731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19637876" @default.
• W2043601731 hasPublicationYear "2009" @default.
• W2043601731 type Work @default.
• W2043601731 sameAs 2043601731 @default.
• W2043601731 citedByCount "45" @default.
• W2043601731 countsByYear W20436017312012 @default.
• W2043601731 countsByYear W20436017312013 @default.
• W2043601731 countsByYear W20436017312014 @default.
• W2043601731 countsByYear W20436017312015 @default.
• W2043601731 countsByYear W20436017312016 @default.
• W2043601731 countsByYear W20436017312018 @default.
• W2043601731 countsByYear W20436017312019 @default.
• W2043601731 countsByYear W20436017312020 @default.
• W2043601731 countsByYear W20436017312021 @default.
• W2043601731 countsByYear W20436017312022 @default.
• W2043601731 countsByYear W20436017312023 @default.
• W2043601731 crossrefType "journal-article" @default.
• W2043601731 hasAuthorship W2043601731A5018427690 @default.
• W2043601731 hasAuthorship W2043601731A5046570644 @default.
• W2043601731 hasAuthorship W2043601731A5049721969 @default.
• W2043601731 hasAuthorship W2043601731A5081866388 @default.
• W2043601731 hasAuthorship W2043601731A5085169432 @default.
• W2043601731 hasBestOaLocation W20436017312 @default.
• W2043601731 hasConcept C147483822 @default.
• W2043601731 hasConcept C185592680 @default.
• W2043601731 hasConcept C202751555 @default.
• W2043601731 hasConcept C203014093 @default.
• W2043601731 hasConcept C2776090121 @default.
• W2043601731 hasConcept C2779244956 @default.
• W2043601731 hasConcept C55493867 @default.
• W2043601731 hasConcept C67662055 @default.
• W2043601731 hasConcept C86803240 @default.
• W2043601731 hasConcept C8891405 @default.
• W2043601731 hasConcept C95444343 @default.
• W2043601731 hasConceptScore W2043601731C147483822 @default.
• W2043601731 hasConceptScore W2043601731C185592680 @default.
• W2043601731 hasConceptScore W2043601731C202751555 @default.
• W2043601731 hasConceptScore W2043601731C203014093 @default.
• W2043601731 hasConceptScore W2043601731C2776090121 @default.
• W2043601731 hasConceptScore W2043601731C2779244956 @default.

• next