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- W2043607595 abstract "Epinephrine has been studied extensively as a physiologic and as a pharmacologic agent. The subject has wide ramifications, and only what appear to be the most significant findings can be discussed in the space available. ISOLATION OF EPINEPHRINE The staining reactions described by Vulpian (green color with ferric chloride) and by Henle (brownish yellow color with dichromates) offered the first evidence for the presence in the medulla of the adrenal gland of a substance absent from most other tissues. Following the observation by Oliver and Schafer 1 of the remarkable pressor effect of extracts of the adrenal medulla, intensive efforts were made to isolate the blood pressure-raising principle. Takamine 2 and Aldrich 3 isolated the free base, while Abel 4 reported the isolation of a crystalline substance, which was later shown to be a benzoyl derivative formed during isolation. The name epinephrine, proposed by Abel for this derivative, was subsequently" @default.
- W2043607595 created "2016-06-24" @default.
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- W2043607595 date "1941-06-07" @default.
- W2043607595 modified "2023-10-18" @default.
- W2043607595 title "THE ADRENAL MEDULLA" @default.
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- W2043607595 doi "https://doi.org/10.1001/jama.1941.62820230008010a" @default.
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