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• W2043609912 abstract "Although inflammation is a physiologic response designed to protect us from infection, when unchecked and ongoing it may cause substantial harm. Both chronic heart failure (CHF) and chronic kidney disease (CKD) are known to cause elaboration of several pro-inflammatory mediators that can be detected at high concentrations in the tissues and blood stream. The biologic sources driving this chronic inflammatory state in CHF and CKD are not fully established. Traditional sources of inflammation include the heart and the kidneys which produce a wide range of pro-inflammatory cytokines in response to neurohormones and sympathetic activation. However, growing evidence suggests that non-traditional biomechanical mechanisms such as venous and tissue congestion due to volume overload are also important as they stimulate endotoxin absorption from the bowel and peripheral synthesis and release of pro-inflammatory mediators. Both during the chronic phase and, more rapidly, during acute exacerbations of CHF and CKD, inflammation and congestion appear to amplify each other resulting in a downward spiral of worsening cardiac, vascular, and renal functions that may negatively impact patients’ outcome. Anti-inflammatory treatment strategies aimed at attenuating end organ damage and improving clinical prognosis in the cardiorenal syndrome have been disappointing to date. A new therapeutic paradigm may be needed, which involves different anti-inflammatory strategies for individual etiologies and stages of CHF and CKD. It may also include specific (short-term) anti-inflammatory treatments that counteract inflammation during the unsettled phases of clinical decompensation. Finally, it will require greater focus on volume overload as an increasingly significant source of systemic inflammation in the cardiorenal syndrome." @default.
• W2043609912 created "2016-06-24" @default.
• W2043609912 creator A5013925577 @default.
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• W2043609912 creator A5049562015 @default.
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• W2043609912 creator A5077575390 @default.
• W2043609912 date "2011-06-19" @default.
• W2043609912 modified "2023-10-01" @default.
• W2043609912 title "Inflammatory activation: cardiac, renal, and cardio-renal interactions in patients with the cardiorenal syndrome" @default.
• W2043609912 cites W1523775390 @default.
• W2043609912 cites W1572089515 @default.
• W2043609912 cites W1681070212 @default.
• W2043609912 cites W1697389429 @default.
• W2043609912 cites W189074344 @default.
• W2043609912 cites W1904996112 @default.
• W2043609912 cites W1965471585 @default.
• W2043609912 cites W1966836886 @default.
• W2043609912 cites W1967808276 @default.
• W2043609912 cites W1968709826 @default.
• W2043609912 cites W1969371344 @default.
• W2043609912 cites W1971167098 @default.
• W2043609912 cites W1975352159 @default.
• W2043609912 cites W1975370982 @default.
• W2043609912 cites W1975999440 @default.
• W2043609912 cites W1978103463 @default.
• W2043609912 cites W1979517335 @default.
• W2043609912 cites W1980468558 @default.
• W2043609912 cites W1983124736 @default.
• W2043609912 cites W1983390800 @default.
• W2043609912 cites W1983523234 @default.
• W2043609912 cites W1984235771 @default.
• W2043609912 cites W1987021368 @default.
• W2043609912 cites W1987473934 @default.
• W2043609912 cites W1990053503 @default.
• W2043609912 cites W1995956780 @default.
• W2043609912 cites W1996391272 @default.
• W2043609912 cites W1996956870 @default.
• W2043609912 cites W1997332439 @default.
• W2043609912 cites W1997488269 @default.
• W2043609912 cites W1998361432 @default.
• W2043609912 cites W1998846386 @default.
• W2043609912 cites W2001302562 @default.
• W2043609912 cites W2002035486 @default.
• W2043609912 cites W2002173300 @default.
• W2043609912 cites W2002747645 @default.
• W2043609912 cites W2003276934 @default.
• W2043609912 cites W2003375015 @default.
• W2043609912 cites W2003701386 @default.
• W2043609912 cites W2005056683 @default.
• W2043609912 cites W2006244753 @default.
• W2043609912 cites W2008588375 @default.
• W2043609912 cites W2009196421 @default.
• W2043609912 cites W2009769042 @default.
• W2043609912 cites W2010912810 @default.
• W2043609912 cites W2011148532 @default.
• W2043609912 cites W2013752497 @default.
• W2043609912 cites W2016677731 @default.
• W2043609912 cites W2017769012 @default.
• W2043609912 cites W2020604058 @default.
• W2043609912 cites W2020761980 @default.
• W2043609912 cites W2024172569 @default.
• W2043609912 cites W2024395573 @default.
• W2043609912 cites W2025029555 @default.
• W2043609912 cites W2027712499 @default.
• W2043609912 cites W2028777035 @default.
• W2043609912 cites W2029114804 @default.
• W2043609912 cites W2029310154 @default.
• W2043609912 cites W2036718044 @default.
• W2043609912 cites W2039014736 @default.
• W2043609912 cites W2039650153 @default.
• W2043609912 cites W2039962907 @default.
• W2043609912 cites W2043414532 @default.
• W2043609912 cites W2044039065 @default.
• W2043609912 cites W2046177442 @default.
• W2043609912 cites W2047959829 @default.
• W2043609912 cites W2051172686 @default.
• W2043609912 cites W2051616579 @default.
• W2043609912 cites W2051969301 @default.
• W2043609912 cites W2053604131 @default.
• W2043609912 cites W2054571110 @default.
• W2043609912 cites W2057609999 @default.
• W2043609912 cites W2058821890 @default.
• W2043609912 cites W2059062679 @default.
• W2043609912 cites W2060493797 @default.
• W2043609912 cites W2061974967 @default.
• W2043609912 cites W2063254774 @default.
• W2043609912 cites W2066885413 @default.
• W2043609912 cites W2066920893 @default.
• W2043609912 cites W2070515423 @default.
• W2043609912 cites W2071209404 @default.
• W2043609912 cites W2072376419 @default.
• W2043609912 cites W2075997785 @default.
• W2043609912 cites W2076356534 @default.
• W2043609912 cites W2077026668 @default.

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