FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043618200> ?p ?o ?g. }

• W2043618200 endingPage "169" @default.
• W2043618200 startingPage "158" @default.
• W2043618200 abstract "The hexosamine biosynthetic pathway (HBP) culminates in the attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) onto serine/threonine residues of target proteins. The HBP is regulated by several modulators, i.e. O-linked β-N-acetylglucosaminyl transferase (OGT) and β-N-acetylglucosaminidase (OGA) catalyze the addition and removal of O-GlcNAc moieties, respectively; while flux is controlled by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFPT), transcribed by two genes, GFPT1 and GFPT2. Since increased HBP flux is glucose-responsive and linked to insulin resistance/type 2 diabetes onset, we hypothesized that diabetic individuals exhibit differential expression of HBP regulatory genes. Volunteers (n = 60; n = 20 Mixed Ancestry, n = 40 Caucasian) were recruited from Stellenbosch and Paarl (Western Cape, South Africa) and classified as control, pre- or diabetic according to fasting plasma glucose and HbA1c levels, respectively. RNA was purified from leukocytes isolated from collected blood samples and OGT, OGA, GFPT1 and GFPT2 expressions determined by quantitative real-time PCR. The data reveal lower OGA expression in diabetic individuals (P < 0.01), while pre- and diabetic subjects displayed attenuated OGT expression vs. controls (P < 0.01 and P < 0.001, respectively). Moreover, GFPT2 expression decreased in pre- and diabetic Caucasians vs. controls (P < 0.05 and P < 0.01, respectively). We also found ethnic differences, i.e. Mixed Ancestry individuals exhibited a 2.4-fold increase in GFPT2 expression vs. Caucasians, despite diagnosis (P < 0.01). Gene expression of HBP regulators differs between diabetic and non-diabetic individuals, together with distinct ethnic-specific gene profiles. Thus differential HBP gene regulation may offer diagnostic utility and provide candidate susceptibility genes for different ethnic groupings." @default.
• W2043618200 created "2016-06-24" @default.
• W2043618200 creator A5040595417 @default.
• W2043618200 creator A5043246967 @default.
• W2043618200 date "2014-01-01" @default.
• W2043618200 modified "2023-10-16" @default.
• W2043618200 title "Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes" @default.
• W2043618200 cites W1590732591 @default.
• W2043618200 cites W1996129941 @default.
• W2043618200 cites W2004600809 @default.
• W2043618200 cites W2013684433 @default.
• W2043618200 cites W2031087463 @default.
• W2043618200 cites W2035837644 @default.
• W2043618200 cites W2041967294 @default.
• W2043618200 cites W2044437167 @default.
• W2043618200 cites W2054664745 @default.
• W2043618200 cites W2061011762 @default.
• W2043618200 cites W2067729127 @default.
• W2043618200 cites W2068322375 @default.
• W2043618200 cites W2068805128 @default.
• W2043618200 cites W2073296546 @default.
• W2043618200 cites W2076651708 @default.
• W2043618200 cites W2089465141 @default.
• W2043618200 cites W2096443403 @default.
• W2043618200 cites W2103642791 @default.
• W2043618200 cites W2118582731 @default.
• W2043618200 cites W2118903190 @default.
• W2043618200 cites W2119816935 @default.
• W2043618200 cites W2121513967 @default.
• W2043618200 cites W2122359598 @default.
• W2043618200 cites W2130135884 @default.
• W2043618200 cites W2153093545 @default.
• W2043618200 cites W2156849498 @default.
• W2043618200 cites W2158841256 @default.
• W2043618200 cites W2164129276 @default.
• W2043618200 doi "https://doi.org/10.1016/j.ymgmr.2014.03.003" @default.
• W2043618200 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5121314" @default.
• W2043618200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27896086" @default.
• W2043618200 hasPublicationYear "2014" @default.
• W2043618200 type Work @default.
• W2043618200 sameAs 2043618200 @default.
• W2043618200 citedByCount "12" @default.
• W2043618200 countsByYear W20436182002016 @default.
• W2043618200 countsByYear W20436182002017 @default.
• W2043618200 countsByYear W20436182002018 @default.
• W2043618200 countsByYear W20436182002019 @default.
• W2043618200 countsByYear W20436182002020 @default.
• W2043618200 countsByYear W20436182002021 @default.
• W2043618200 countsByYear W20436182002023 @default.
• W2043618200 crossrefType "journal-article" @default.
• W2043618200 hasAuthorship W2043618200A5040595417 @default.
• W2043618200 hasAuthorship W2043618200A5043246967 @default.
• W2043618200 hasBestOaLocation W20436182001 @default.
• W2043618200 hasConcept C104317684 @default.
• W2043618200 hasConcept C126322002 @default.
• W2043618200 hasConcept C134018914 @default.
• W2043618200 hasConcept C150194340 @default.
• W2043618200 hasConcept C181199279 @default.
• W2043618200 hasConcept C2777180221 @default.
• W2043618200 hasConcept C2777391703 @default.
• W2043618200 hasConcept C2779349466 @default.
• W2043618200 hasConcept C515207424 @default.
• W2043618200 hasConcept C55493867 @default.
• W2043618200 hasConcept C555293320 @default.
• W2043618200 hasConcept C71924100 @default.
• W2043618200 hasConcept C75972863 @default.
• W2043618200 hasConcept C86803240 @default.
• W2043618200 hasConceptScore W2043618200C104317684 @default.
• W2043618200 hasConceptScore W2043618200C126322002 @default.
• W2043618200 hasConceptScore W2043618200C134018914 @default.
• W2043618200 hasConceptScore W2043618200C150194340 @default.
• W2043618200 hasConceptScore W2043618200C181199279 @default.
• W2043618200 hasConceptScore W2043618200C2777180221 @default.
• W2043618200 hasConceptScore W2043618200C2777391703 @default.
• W2043618200 hasConceptScore W2043618200C2779349466 @default.
• W2043618200 hasConceptScore W2043618200C515207424 @default.
• W2043618200 hasConceptScore W2043618200C55493867 @default.
• W2043618200 hasConceptScore W2043618200C555293320 @default.
• W2043618200 hasConceptScore W2043618200C71924100 @default.
• W2043618200 hasConceptScore W2043618200C75972863 @default.
• W2043618200 hasConceptScore W2043618200C86803240 @default.
• W2043618200 hasFunder F4320322663 @default.
• W2043618200 hasLocation W20436182001 @default.
• W2043618200 hasLocation W20436182002 @default.
• W2043618200 hasLocation W20436182003 @default.
• W2043618200 hasLocation W20436182004 @default.
• W2043618200 hasLocation W20436182005 @default.
• W2043618200 hasOpenAccess W2043618200 @default.
• W2043618200 hasPrimaryLocation W20436182001 @default.
• W2043618200 hasRelatedWork W1979252938 @default.
• W2043618200 hasRelatedWork W2032225465 @default.
• W2043618200 hasRelatedWork W2118505283 @default.
• W2043618200 hasRelatedWork W2169206971 @default.
• W2043618200 hasRelatedWork W2378290744 @default.
• W2043618200 hasRelatedWork W2584731720 @default.
• W2043618200 hasRelatedWork W2886303208 @default.
• W2043618200 hasRelatedWork W2910989958 @default.
• W2043618200 hasRelatedWork W2915111749 @default.

• next