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• W2043632912 startingPage "e29513" @default.
• W2043632912 abstract "Resveratrol is a plant-derived polyphenol that extends lifespan and healthspan in model organism. Despite extensive investigation, the biological processes mediating resveratrol's effects have yet to be elucidated. Because repression of translation shares many of resveratrol's beneficial effects, we hypothesized that resveratrol was a modulator of protein synthesis. We studied the effect of the drug on the H4-II-E rat hepatoma cell line. Initial studies showed that resveratrol inhibited global protein synthesis. Given the role of the mammalian Target of Rapamycin (mTOR) in regulating protein synthesis, we examined the effect of resveratrol on mTOR signaling. Resveratrol inhibited mTOR self-phosphorylation and the phosphorylation of mTOR targets S6K1 and eIF4E-BP1. It attenuated the formation of the translation initiation complex eIF4F and increased the phosphorylation of eIF2α. The latter event, also a mechanism for translation inhibition, was not recapitulated by mTOR inhibitors. The effects on mTOR signaling were independent of effects on AMP-activated kinase or AKT. We conclude that resveratrol is an inhibitor of global protein synthesis, and that this effect is mediated through modulation of mTOR-dependent and independent signaling." @default.
• W2043632912 created "2016-06-24" @default.
• W2043632912 creator A5018677268 @default.
• W2043632912 creator A5048198050 @default.
• W2043632912 creator A5064291074 @default.
• W2043632912 creator A5078608377 @default.
• W2043632912 date "2011-12-29" @default.
• W2043632912 modified "2023-10-03" @default.
• W2043632912 title "Resveratrol Inhibits Protein Translation in Hepatic Cells" @default.
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• W2043632912 cites W177963654 @default.
• W2043632912 cites W1963749523 @default.
• W2043632912 cites W1966082815 @default.
• W2043632912 cites W1972734616 @default.
• W2043632912 cites W1992657370 @default.
• W2043632912 cites W2002226709 @default.
• W2043632912 cites W2002248582 @default.
• W2043632912 cites W2002741326 @default.
• W2043632912 cites W2006559495 @default.
• W2043632912 cites W2008825756 @default.
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• W2043632912 cites W2020476652 @default.
• W2043632912 cites W2022059412 @default.
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• W2043632912 doi "https://doi.org/10.1371/journal.pone.0029513" @default.
• W2043632912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248458" @default.
• W2043632912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242130" @default.
• W2043632912 hasPublicationYear "2011" @default.
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