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• W2043648109 abstract "Verrucous carcinoma was Wrst reported by Friedell and Rosenthal [1], who described eight lesions of a verrucoid nature in the buccal mucosa and alveolar ridge of tobacco chewers. In 1948, one of the deans of US surgical pathology, Lauren V. Ackerman [2] reported on a vexing lesion arising in the head and neck region. This lesion was a squamoproliferative lesion with a capacity for locally destructive behavior, but a most deceptively bland light microscopic appearance. Ackerman [2] clearly deWned the morphological and biological features of this neoplasm, coining the term “verrucous carcinoma”. At roughly the same time, a prominent British surgeon, Aird reported a similar lesion arising from the skin of the foot [3]. Both of these reports—Ackerman’s verrucous carcinoma and Aird’s carcinoma cuniculatum (so named because of the resemblance of the deeply inWltrating tongues of tumor to rabbit burrows)—described the same lesion arising in diVerent locales, a lesion marked by an exophytic warty appearance and a tendency to push deeply into the underlying tissues. Verrucous carcinoma is now known to arise in a variety of epithelial sites, most often the oral mucosa, the larynx, the skin of the genitalia, and the skin of the plantar aspect of the foot [4–7]. Cervical and distant metastases have not been reported in cases of classic verrucous carcinoma [8, 9]. Histological examination of any enlarged lymph nodes has revealed only reactive changes and not metastases [9]. Virtually all cases of alleged metastatic verrucous carcinomas are conventional exophytic well-diVerentiated carcinomas mislabeled as verrucous or they are unrecognized hybrid verrucous carcinomas. This tumor poses chieXy a problem in local control only, in light of its locally destructive character." @default.
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• W2043648109 date "2011-02-01" @default.
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• W2043648109 title "Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: what do we know now that we did not know a decade ago?" @default.
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• W2043648109 doi "https://doi.org/10.1007/s00405-011-1495-0" @default.
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