FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043668319> ?p ?o ?g. }

• W2043668319 endingPage "916" @default.
• W2043668319 startingPage "912" @default.
• W2043668319 abstract "1. It has been suggested that leukocytes play a key role in the pathogenesis of splanchnic artery occlusion shock. Intercellular adhesion molecule 1 (ICAM-1) is an adhesion molecule of crucial importance in the phenomenon of leukocyte accumulation. 2. We investigated the involvement of ICAM-1 in the pathogenesis of splanchnic artery occlusion shock. Splanchnic artery occlusion (SAO) shock was induced in anaesthetized rats by clamping splanchnic arteries for 45 min. Sham-operated animals were used as controls. Survival time, serum tumour necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase activity (MPO; studied as a quantitative means to assess leukocyte accumulation) and the responsiveness to acetylcholine of aortic rings were investigated. SAO shocked rats had a decreased survival time (90 +/- 9.5 min, while sham-shocked rats survived more than 4 h), reduced mean arterial blood pressure, increased serum levels of TNF-alpha (201 +/- 10 mu ml-1) and MPO activity in the ileum (0.15 +/- 0.03 mu x 10(-3) per g tissue) and in the lung (1.9 +/- 0.8 mu x 10(-3) per g tissue), leukopenia and reduced responsiveness to acetylcholine (ACh, 10 nM-10 microM) of aortic rings. 3. Administration of monoclonal antibody raised against rat ICAM-1 significantly increased survival time (225 +/- 9 min), reduced leukopenia and MPO activity both in the ileum (0.031 +/- 0.003 mu x 10(-3) per g tissue) and in the lung 0.23 +/- 0.03 mu x 10(-3) per g tissue), improved the cardiovascular changes and restored the responsiveness to ACh of aortic rings. 4. Our findings are consistent with an involvement of adhesion mechanisms in vivo in the pathogenesis of SAO shock and suggest that specific adhesion mechanisms, which support leukocyte accumulation,may represent potentially important therapeutic targets in circulatory shock." @default.
• W2043668319 created "2016-06-24" @default.
• W2043668319 creator A5001079899 @default.
• W2043668319 creator A5021100401 @default.
• W2043668319 creator A5034283699 @default.
• W2043668319 creator A5052729205 @default.
• W2043668319 creator A5054429253 @default.
• W2043668319 creator A5059353158 @default.
• W2043668319 creator A5067037077 @default.
• W2043668319 creator A5074240594 @default.
• W2043668319 creator A5075607184 @default.
• W2043668319 creator A5080680155 @default.
• W2043668319 date "1994-11-01" @default.
• W2043668319 modified "2023-09-27" @default.
• W2043668319 title "Contribution of intercellular adhesion molecule 1 (ICAM-1) to the pathogenesis of splanchnic artery occlusion shock in the rat" @default.
• W2043668319 cites W1510169018 @default.
• W2043668319 cites W1522456251 @default.
• W2043668319 cites W1529651253 @default.
• W2043668319 cites W1572295857 @default.
• W2043668319 cites W1793781643 @default.
• W2043668319 cites W1956079086 @default.
• W2043668319 cites W1977788083 @default.
• W2043668319 cites W1985204948 @default.
• W2043668319 cites W1995948010 @default.
• W2043668319 cites W2011207006 @default.
• W2043668319 cites W2015037737 @default.
• W2043668319 cites W2019405807 @default.
• W2043668319 cites W2020268768 @default.
• W2043668319 cites W2026573227 @default.
• W2043668319 cites W2037532439 @default.
• W2043668319 cites W2042375104 @default.
• W2043668319 cites W2050286820 @default.
• W2043668319 cites W2057784785 @default.
• W2043668319 cites W2066106574 @default.
• W2043668319 cites W2081279199 @default.
• W2043668319 cites W2088073163 @default.
• W2043668319 cites W2090169073 @default.
• W2043668319 cites W2116925086 @default.
• W2043668319 cites W2141934523 @default.
• W2043668319 cites W2194405407 @default.
• W2043668319 cites W2259392365 @default.
• W2043668319 cites W2289992901 @default.
• W2043668319 cites W2408570893 @default.
• W2043668319 cites W2411772203 @default.
• W2043668319 cites W2424587497 @default.
• W2043668319 cites W2462433304 @default.
• W2043668319 cites W4290295577 @default.
• W2043668319 doi "https://doi.org/10.1111/j.1476-5381.1994.tb17079.x" @default.
• W2043668319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1510450" @default.
• W2043668319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7858885" @default.
• W2043668319 hasPublicationYear "1994" @default.
• W2043668319 type Work @default.
• W2043668319 sameAs 2043668319 @default.
• W2043668319 citedByCount "22" @default.
• W2043668319 crossrefType "journal-article" @default.
• W2043668319 hasAuthorship W2043668319A5001079899 @default.
• W2043668319 hasAuthorship W2043668319A5021100401 @default.
• W2043668319 hasAuthorship W2043668319A5034283699 @default.
• W2043668319 hasAuthorship W2043668319A5052729205 @default.
• W2043668319 hasAuthorship W2043668319A5054429253 @default.
• W2043668319 hasAuthorship W2043668319A5059353158 @default.
• W2043668319 hasAuthorship W2043668319A5067037077 @default.
• W2043668319 hasAuthorship W2043668319A5074240594 @default.
• W2043668319 hasAuthorship W2043668319A5075607184 @default.
• W2043668319 hasAuthorship W2043668319A5080680155 @default.
• W2043668319 hasBestOaLocation W20436683192 @default.
• W2043668319 hasConcept C126322002 @default.
• W2043668319 hasConcept C134018914 @default.
• W2043668319 hasConcept C142724271 @default.
• W2043668319 hasConcept C178853913 @default.
• W2043668319 hasConcept C203014093 @default.
• W2043668319 hasConcept C203565725 @default.
• W2043668319 hasConcept C2775849017 @default.
• W2043668319 hasConcept C2775910092 @default.
• W2043668319 hasConcept C2776914184 @default.
• W2043668319 hasConcept C2780942790 @default.
• W2043668319 hasConcept C2781300812 @default.
• W2043668319 hasConcept C71924100 @default.
• W2043668319 hasConceptScore W2043668319C126322002 @default.
• W2043668319 hasConceptScore W2043668319C134018914 @default.
• W2043668319 hasConceptScore W2043668319C142724271 @default.
• W2043668319 hasConceptScore W2043668319C178853913 @default.
• W2043668319 hasConceptScore W2043668319C203014093 @default.
• W2043668319 hasConceptScore W2043668319C203565725 @default.
• W2043668319 hasConceptScore W2043668319C2775849017 @default.
• W2043668319 hasConceptScore W2043668319C2775910092 @default.
• W2043668319 hasConceptScore W2043668319C2776914184 @default.
• W2043668319 hasConceptScore W2043668319C2780942790 @default.
• W2043668319 hasConceptScore W2043668319C2781300812 @default.
• W2043668319 hasConceptScore W2043668319C71924100 @default.
• W2043668319 hasIssue "3" @default.
• W2043668319 hasLocation W20436683191 @default.
• W2043668319 hasLocation W20436683192 @default.
• W2043668319 hasLocation W20436683193 @default.
• W2043668319 hasLocation W20436683194 @default.
• W2043668319 hasOpenAccess W2043668319 @default.
• W2043668319 hasPrimaryLocation W20436683191 @default.
• W2043668319 hasRelatedWork W1993142192 @default.

• next