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- W2043674502 abstract "Abstract A number of nitrosamines and structurally or functionally related agents were tested for their ability to produce chromosomal aberrations in the root-tips of Vicia faba . Of these agents only cupferron, N-methylphenylnitrosamine (MPNA), and nitric oxide were active. The radiomimetic effect of MPNA was studied more in detail and compared with that of cupferron. MPNA had a delayed effect. The aberrations, which were exclusively of the chromatid type, tended to be localized into heterochromatic parts of the chromosomes, but were rather evenly distributed between the chromosomes. In contrast to the effect of cupferron, the radiomimetic effect of MPNA was independent of the pH and the temperature of the treatment solution. Both MPNA and cupferron were almost inactive in the absence of oxygen but, whereas the effect of cupferron was independent of oxygen concentrations between 1 and 100 per cent, that of MPNA increased along with the oxygen concentration up to 100 per cent. The radiomimetic effect of MPNA was suppressed by agents reacting with heavy metals (sodium azide, cupferron), but was not significantly affected by the uncoupling agent 2.4-dinitrophenol. It was concluded that the active agent is not the phenylnitrosamine per se , but some decomposition product formed in the presence of oxygen and a heavy metal containing enzyme." @default.
- W2043674502 created "2016-06-24" @default.
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- W2043674502 date "1961-01-01" @default.
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- W2043674502 title "Gytological effects of phenylnitrosamines—II. Radiomimetic effects" @default.
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- W2043674502 doi "https://doi.org/10.1016/s0033-7560(61)80005-7" @default.
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