Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043677425> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2043677425 endingPage "1919" @default.
- W2043677425 startingPage "1907" @default.
- W2043677425 abstract "Die intramolekulare Wittig-Reaktion des Ylids 8b fuhrt zum Dihydronaphthacen 9b, das durch cis-Hydroxylierung und Pyridiniumchlorochromat-Oxidation zum Ketol 16 umgewandelt werden kann. Eine Hydroxygruppe an C-4 kann entweder durch Bromierung — gefolgt von Behandlung mit verdunntem Alkali — oder durch direkte basenkatalysierte Hydroxylierung eingefuhrt werden und liefert mit hoher Stereoselektivitat das 2,4-cis-Diol 18. Die Reaktion der Bromierungsprodukte 17a/17b mit Silber-trifluormethansulfonat ergibt hauptsachlich das epimere 2,4-trans-Diol 19 (3-Desmethoxyaranciamycinon) neben geringeren Mengen 18 und dem Eliminierungsprodukt 20.Synthetic Anthracyclinones, XXI1). — Synthesis of 3-DemethoxyaranciamycinoneThe intramolecular Wittig reaction of the ylide 8b leads to the dihydronaphthacene 9b which can be transformed into the ketol 16 by cis-hydroxylation and pyridinium chlorochromate oxidation. A hydroxy group at C-4 can be introduced either by bromination followed by treatment with diluted alkali or by direct base catalysed hydroxylation leading to the 2,4-cis-diol 18 with high stereoselectivity. The reaction of the bromination products 17a/17b with silver trifluoromethane-sulfonate predominately yields the epimeric 2,4-trans-diol 19 (3-demethoxyaranciamycinone) besides minor amounts of 18 and the elimination product 20." @default.
- W2043677425 created "2016-06-24" @default.
- W2043677425 creator A5012295583 @default.
- W2043677425 creator A5073695928 @default.
- W2043677425 date "1982-10-18" @default.
- W2043677425 modified "2023-10-16" @default.
- W2043677425 title "Synthetische Anthracyclinone, XXI. Synthese des 3-Desmethoxyaranciamycinons" @default.
- W2043677425 cites W1976625106 @default.
- W2043677425 cites W2050538350 @default.
- W2043677425 cites W2059307021 @default.
- W2043677425 cites W2079572328 @default.
- W2043677425 cites W2133928176 @default.
- W2043677425 cites W2147435866 @default.
- W2043677425 cites W2322551531 @default.
- W2043677425 doi "https://doi.org/10.1002/jlac.198219821012" @default.
- W2043677425 hasPublicationYear "1982" @default.
- W2043677425 type Work @default.
- W2043677425 sameAs 2043677425 @default.
- W2043677425 citedByCount "11" @default.
- W2043677425 countsByYear W20436774252013 @default.
- W2043677425 countsByYear W20436774252019 @default.
- W2043677425 crossrefType "journal-article" @default.
- W2043677425 hasAuthorship W2043677425A5012295583 @default.
- W2043677425 hasAuthorship W2043677425A5073695928 @default.
- W2043677425 hasConcept C155647269 @default.
- W2043677425 hasConcept C161790260 @default.
- W2043677425 hasConcept C178790620 @default.
- W2043677425 hasConcept C181199279 @default.
- W2043677425 hasConcept C181647583 @default.
- W2043677425 hasConcept C185592680 @default.
- W2043677425 hasConcept C24292678 @default.
- W2043677425 hasConcept C2777221202 @default.
- W2043677425 hasConcept C2778948405 @default.
- W2043677425 hasConcept C2779167645 @default.
- W2043677425 hasConcept C2779515768 @default.
- W2043677425 hasConcept C2781109383 @default.
- W2043677425 hasConcept C65973085 @default.
- W2043677425 hasConcept C71240020 @default.
- W2043677425 hasConcept C75079739 @default.
- W2043677425 hasConceptScore W2043677425C155647269 @default.
- W2043677425 hasConceptScore W2043677425C161790260 @default.
- W2043677425 hasConceptScore W2043677425C178790620 @default.
- W2043677425 hasConceptScore W2043677425C181199279 @default.
- W2043677425 hasConceptScore W2043677425C181647583 @default.
- W2043677425 hasConceptScore W2043677425C185592680 @default.
- W2043677425 hasConceptScore W2043677425C24292678 @default.
- W2043677425 hasConceptScore W2043677425C2777221202 @default.
- W2043677425 hasConceptScore W2043677425C2778948405 @default.
- W2043677425 hasConceptScore W2043677425C2779167645 @default.
- W2043677425 hasConceptScore W2043677425C2779515768 @default.
- W2043677425 hasConceptScore W2043677425C2781109383 @default.
- W2043677425 hasConceptScore W2043677425C65973085 @default.
- W2043677425 hasConceptScore W2043677425C71240020 @default.
- W2043677425 hasConceptScore W2043677425C75079739 @default.
- W2043677425 hasIssue "10" @default.
- W2043677425 hasLocation W20436774251 @default.
- W2043677425 hasOpenAccess W2043677425 @default.
- W2043677425 hasPrimaryLocation W20436774251 @default.
- W2043677425 hasVolume "1982" @default.
- W2043677425 isParatext "false" @default.
- W2043677425 isRetracted "false" @default.
- W2043677425 magId "2043677425" @default.
- W2043677425 workType "article" @default.