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- W2043679525 abstract "Antigen cross-presentation in dendritic cells is a complex intracellular membrane transport process, but the underlying molecular mechanisms remain to be thoroughly investigated. In this study, we examined the effect of siRNA-mediated knockdown of 57 Rab GTPases, the key regulators of membrane trafficking, on antigen cross-presentation. Twelve Rab GTPases were identified to be associated with antigen cross-presentation, and Rab3b/3c was indicated to be colocalized with MHC class I molecules at perinuclear tubular structure. Tracing with fluorescence protein-tagged β 2 -microglobulin demonstrated that the MHC class I molecules were internalized from the plasma membrane to Rab3b/3c-positive compartments, which were also colocalized with the internalized transferrin. Moreover, depletion of Rab3b/3c strongly reduced the fast phase recycling rate of transferrin receptors. Furthermore, the Rab3b/3c-positive compartments were colocalized with a fraction of Rab27a at a juxtaposition of phagosomes. Together, these data demonstrate that Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation." @default.
- W2043679525 created "2016-06-24" @default.
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- W2043679525 date "2009-09-15" @default.
- W2043679525 modified "2023-10-16" @default.
- W2043679525 title "The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells" @default.
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- W2043679525 doi "https://doi.org/10.1073/pnas.0905684106" @default.
- W2043679525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747199" @default.
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- W2043679525 hasPublicationYear "2009" @default.
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