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• W2043680807 abstract "Given the presence of continuous endogenous and exogenous sources of stress, mammalian species have evolved complex systems of protection, detoxification and repair, in order to maintain homeostasis during development and until reproductive maturity for the sake of the species. However, since no system is perfect, complete prevention of damage is unlikely to occur. Accumulation of macromolecular damage, including damage to DNA and genomic instability, is considered a driving force for the ageing process and age-related diseases. One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribosyl)ation is involved in DNA base-excision repair (BER), DNA-damage signalling and regulation of genomic stability. In recent years, many groups have become involved in PARP field, shedding light on new partners for PARP-1, new members of the PARP family and new physiological and pathophysiological properties for the founding member of the poly(ADP-ribose) polymerase super family. The present review focuses on PARP-1 and its role in the maintenance of genome stability and in mammalian longevity." @default.
• W2043680807 created "2016-06-24" @default.
• W2043680807 creator A5077555067 @default.
• W2043680807 date "2003-04-01" @default.
• W2043680807 modified "2023-09-27" @default.
• W2043680807 title "Mammalian longevity under the protection of PARP-1’s multi-facets" @default.
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• W2043680807 doi "https://doi.org/10.1016/s1568-1637(02)00062-4" @default.
• W2043680807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12605957" @default.
• W2043680807 hasPublicationYear "2003" @default.
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