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• W2043685200 abstract "In view of recent knowledge on proteins regulating the cell cycle, we re-evaluated proliferative features of 98 diffusely growing non-Hodgkin's lymphomas. The combined use of 5 proliferation–associated variables (mitotic indices and percentages of Ki-67+, p34cdc2+, cyclin A+ and cyclin B+ cells) and their entry into a multivariate cluster analysis separated, without overlaps, the entire cohort into 3 groups (clusters) with (1) low, (2) intermediate and (3) high proliferative activity. Conversely, bivariate plots exposed considerable cluster overlaps. Multivariate stepwise discriminant analysis of all cases revealed a decreasing order of discriminant power for % Ki-67+ cells > % p34cdc2+ cells > mitotic index > % cyclin A+ cells > % cyclin B+ cells. The combined use of 2 variables only, mitotic index and % p34cdc2+ cells, allowed a clear-cut separation of clusters 2 and 3. In bivariate plots, correlations were best between % Ki-67+ cells and % cyclin A+ cells and between mitotic indices and % cyclin B+ cells. Except for chronic lymphocytic leukemias, immunocytomas and marginal zone lymphomas (all in cluster 1), individual lymphoma entities were distributed among at least 2 clusters. There was, however, a marked preponderance of mantle cell lymphomas and diffuse follicular center lymphomas in cluster 1 and of diffuse large B-cell lymphomas and peripheral T-cell lymphomas in cluster 2. Anaplastic large-cell lymphomas predominated in cluster 3 and responded best to therapy. Int. J. Cancer 83:203–209, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2043685200 date "1999-10-08" @default.
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• W2043685200 title "Expression of p34cdc2 and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: A multivariate cluster analysis" @default.
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• W2043685200 doi "https://doi.org/10.1002/(sici)1097-0215(19991008)83:2<203::aid-ijc10>3.0.co;2-0" @default.
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