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• W2043693346 abstract "ObjectiveAfter the 2009 Canadian Prevention of Multiple Births Roundtable (CPMBR), Canadian IVF programs agreed to reach the following targets by 2015: reduce twin rate to 15%, increase use of single embryo transfer (eSET) to 50% of good prognosis patients and eliminate higher order multiples entirely.DesignA prospective analysis of eSET utilization, clinical pregnancy, implantation and multiple pregnancy rates for all IVF patients under 40 years to monitor CPMBR target compliance.Materials and MethodsProspective data collection of all embryo transfers (ET) performed from January 2010 through March 2011 in a private Canadian IVF program. All embryos were cultured in Quinn Advantage Protein Plus sequential media in Cook and Origio mini-incubators maintained at 6% CO2 and 5% O2. Embryo transfer decisions were based on the following criteria: patients with two or less zygotes had Day 2 ET, patients with 4 or more high quality day 3 pushed to Day 5 ET with Day 5 eSET determined by physician and patient at Day 5 ET time and the remaining patients had Day 3 ET. Data were evaluated by chi square analyses.ResultsA total of 929 ET was performed (16% day 2, 45% day 3 and 40% day 5) with eSET being performed 1% at day 3 and 41% at day 5. A total of 447 patients were candidates for blastocyst transfer and possible eSET but only 312 patients had a day 5 ET for various reasons. Clinical pregnancy and implantation rates were significantly different in patients receiving a day 3 multiple ET vs. day 5 double ET or day 5 eSET (55%/29% vs. 73%/50% vs 71%/65%, P<0.01). The day 3 multiple ET and day 5 eSET had significantly lower twin and triplet rates vs. day 5 double ET [15%/0.3% vs 4% (monozygotic)/0% vs. 41%/1% (monozygotic) P<0.01].ConclusionThe implementation of a successful blastocyst culture and eSET program in women under 40 years can effectively eliminate the incidence of twins and triplets while maintaining high pregnancy and implantation rates. ObjectiveAfter the 2009 Canadian Prevention of Multiple Births Roundtable (CPMBR), Canadian IVF programs agreed to reach the following targets by 2015: reduce twin rate to 15%, increase use of single embryo transfer (eSET) to 50% of good prognosis patients and eliminate higher order multiples entirely. After the 2009 Canadian Prevention of Multiple Births Roundtable (CPMBR), Canadian IVF programs agreed to reach the following targets by 2015: reduce twin rate to 15%, increase use of single embryo transfer (eSET) to 50% of good prognosis patients and eliminate higher order multiples entirely. DesignA prospective analysis of eSET utilization, clinical pregnancy, implantation and multiple pregnancy rates for all IVF patients under 40 years to monitor CPMBR target compliance. A prospective analysis of eSET utilization, clinical pregnancy, implantation and multiple pregnancy rates for all IVF patients under 40 years to monitor CPMBR target compliance. Materials and MethodsProspective data collection of all embryo transfers (ET) performed from January 2010 through March 2011 in a private Canadian IVF program. All embryos were cultured in Quinn Advantage Protein Plus sequential media in Cook and Origio mini-incubators maintained at 6% CO2 and 5% O2. Embryo transfer decisions were based on the following criteria: patients with two or less zygotes had Day 2 ET, patients with 4 or more high quality day 3 pushed to Day 5 ET with Day 5 eSET determined by physician and patient at Day 5 ET time and the remaining patients had Day 3 ET. Data were evaluated by chi square analyses. Prospective data collection of all embryo transfers (ET) performed from January 2010 through March 2011 in a private Canadian IVF program. All embryos were cultured in Quinn Advantage Protein Plus sequential media in Cook and Origio mini-incubators maintained at 6% CO2 and 5% O2. Embryo transfer decisions were based on the following criteria: patients with two or less zygotes had Day 2 ET, patients with 4 or more high quality day 3 pushed to Day 5 ET with Day 5 eSET determined by physician and patient at Day 5 ET time and the remaining patients had Day 3 ET. Data were evaluated by chi square analyses. ResultsA total of 929 ET was performed (16% day 2, 45% day 3 and 40% day 5) with eSET being performed 1% at day 3 and 41% at day 5. A total of 447 patients were candidates for blastocyst transfer and possible eSET but only 312 patients had a day 5 ET for various reasons. Clinical pregnancy and implantation rates were significantly different in patients receiving a day 3 multiple ET vs. day 5 double ET or day 5 eSET (55%/29% vs. 73%/50% vs 71%/65%, P<0.01). The day 3 multiple ET and day 5 eSET had significantly lower twin and triplet rates vs. day 5 double ET [15%/0.3% vs 4% (monozygotic)/0% vs. 41%/1% (monozygotic) P<0.01]. A total of 929 ET was performed (16% day 2, 45% day 3 and 40% day 5) with eSET being performed 1% at day 3 and 41% at day 5. A total of 447 patients were candidates for blastocyst transfer and possible eSET but only 312 patients had a day 5 ET for various reasons. Clinical pregnancy and implantation rates were significantly different in patients receiving a day 3 multiple ET vs. day 5 double ET or day 5 eSET (55%/29% vs. 73%/50% vs 71%/65%, P<0.01). The day 3 multiple ET and day 5 eSET had significantly lower twin and triplet rates vs. day 5 double ET [15%/0.3% vs 4% (monozygotic)/0% vs. 41%/1% (monozygotic) P<0.01]. ConclusionThe implementation of a successful blastocyst culture and eSET program in women under 40 years can effectively eliminate the incidence of twins and triplets while maintaining high pregnancy and implantation rates. The implementation of a successful blastocyst culture and eSET program in women under 40 years can effectively eliminate the incidence of twins and triplets while maintaining high pregnancy and implantation rates." @default.
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• W2043693346 date "2011-09-01" @default.
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• W2043693346 title "The evaluation of an elective single blastocyst embryo transfer program: monitoring canadian prevention of multiple births roundtable 2015 target goals" @default.
• W2043693346 doi "https://doi.org/10.1016/j.fertnstert.2011.07.072" @default.
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