Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043702948> ?p ?o ?g. }
- W2043702948 endingPage "87" @default.
- W2043702948 startingPage "77" @default.
- W2043702948 abstract "Iron(II) complexes [Fe(L)2]2+ as perchlorate (1–3) and chloride (1a-3a) salts, where L is 4′-phenyl-2,2′:6′,2″-terpyridine (phtpy in 1, 1a), 4′-(9-anthracenyl)-2,2′:6′,2″-terpyridine (antpy in 2, 2a) and 4′-(1-pyrenyl)-2,2′:6′,2″-terpyridine (pytpy in 3, 3a), were prepared and their photocytotoxicity studied. The diamagnetic complexes 1–3 having an FeN6 core showed an Fe(III)–Fe(II) redox couple near 1.0 V vs. saturated calomel electrode in MeCN-0.1 M tetrabutylammonium perchlorate. Complexes 2 and 3, in addition, displayed a quasi-reversible ligand-based redox process near 0.0 V. The redox and spectral properties are rationalized from the theoretical studies. The complexes bind to DNA in a partial intercalative mode. The pytpy complex efficiently photo-cleaves DNA in green light via superoxide and hydroxyl radical formation. The antpy and pytpy complexes exhibited a remarkable photocytotoxic effect in HeLa cancer cells (IC50, ~ 9 μM) in visible light (400–700 nm), while remaining essentially nontoxic in dark (IC50, ~ 90 μM). Formation of reactive oxygen species (ROS) inside the HeLa cells was evidenced from the fluorescence enhancement of dichlorofluorescein upon treatment with the pytpy complex followed by photo-exposure. The antpy and pytpy complexes were used for cellular imaging. Confocal imaging and dual staining study using propidium iodide (PI) showed nuclear localization of the complexes." @default.
- W2043702948 created "2016-06-24" @default.
- W2043702948 creator A5010638335 @default.
- W2043702948 creator A5020978468 @default.
- W2043702948 creator A5041831885 @default.
- W2043702948 creator A5042681217 @default.
- W2043702948 creator A5061505558 @default.
- W2043702948 creator A5074938996 @default.
- W2043702948 date "2012-11-01" @default.
- W2043702948 modified "2023-10-15" @default.
- W2043702948 title "Nuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity" @default.
- W2043702948 cites W1596848781 @default.
- W2043702948 cites W1967190732 @default.
- W2043702948 cites W1978805924 @default.
- W2043702948 cites W1979054703 @default.
- W2043702948 cites W1980075215 @default.
- W2043702948 cites W1980961223 @default.
- W2043702948 cites W1982201293 @default.
- W2043702948 cites W1983515750 @default.
- W2043702948 cites W1989180035 @default.
- W2043702948 cites W1996432261 @default.
- W2043702948 cites W1999782123 @default.
- W2043702948 cites W2000554196 @default.
- W2043702948 cites W2000774559 @default.
- W2043702948 cites W2008075048 @default.
- W2043702948 cites W2012108057 @default.
- W2043702948 cites W2012996727 @default.
- W2043702948 cites W2018815112 @default.
- W2043702948 cites W2023271753 @default.
- W2043702948 cites W2027935944 @default.
- W2043702948 cites W2030026267 @default.
- W2043702948 cites W2030406875 @default.
- W2043702948 cites W2033570313 @default.
- W2043702948 cites W2034120984 @default.
- W2043702948 cites W2044490585 @default.
- W2043702948 cites W2044929148 @default.
- W2043702948 cites W2046918505 @default.
- W2043702948 cites W2047421878 @default.
- W2043702948 cites W2050639256 @default.
- W2043702948 cites W2053987411 @default.
- W2043702948 cites W2061604015 @default.
- W2043702948 cites W2069983479 @default.
- W2043702948 cites W2071167639 @default.
- W2043702948 cites W2075627152 @default.
- W2043702948 cites W2077738035 @default.
- W2043702948 cites W2079819005 @default.
- W2043702948 cites W2084863967 @default.
- W2043702948 cites W2085835127 @default.
- W2043702948 cites W2086654587 @default.
- W2043702948 cites W2091395535 @default.
- W2043702948 cites W2092080533 @default.
- W2043702948 cites W2092184392 @default.
- W2043702948 cites W2092317817 @default.
- W2043702948 cites W2114918609 @default.
- W2043702948 cites W2122141445 @default.
- W2043702948 cites W2123950781 @default.
- W2043702948 cites W2124062102 @default.
- W2043702948 cites W2124551839 @default.
- W2043702948 cites W2124582179 @default.
- W2043702948 cites W2139526957 @default.
- W2043702948 cites W2142597103 @default.
- W2043702948 cites W2143981217 @default.
- W2043702948 cites W2146563007 @default.
- W2043702948 cites W2148767695 @default.
- W2043702948 cites W2152764444 @default.
- W2043702948 cites W2160604202 @default.
- W2043702948 cites W2162994503 @default.
- W2043702948 cites W2165671984 @default.
- W2043702948 cites W2317604061 @default.
- W2043702948 cites W2334679641 @default.
- W2043702948 cites W2952566998 @default.
- W2043702948 cites W45427174 @default.
- W2043702948 doi "https://doi.org/10.1016/j.jinorgbio.2012.06.006" @default.
- W2043702948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23022691" @default.
- W2043702948 hasPublicationYear "2012" @default.
- W2043702948 type Work @default.
- W2043702948 sameAs 2043702948 @default.
- W2043702948 citedByCount "34" @default.
- W2043702948 countsByYear W20437029482014 @default.
- W2043702948 countsByYear W20437029482015 @default.
- W2043702948 countsByYear W20437029482016 @default.
- W2043702948 countsByYear W20437029482017 @default.
- W2043702948 countsByYear W20437029482018 @default.
- W2043702948 countsByYear W20437029482019 @default.
- W2043702948 countsByYear W20437029482020 @default.
- W2043702948 countsByYear W20437029482021 @default.
- W2043702948 countsByYear W20437029482023 @default.
- W2043702948 crossrefType "journal-article" @default.
- W2043702948 hasAuthorship W2043702948A5010638335 @default.
- W2043702948 hasAuthorship W2043702948A5020978468 @default.
- W2043702948 hasAuthorship W2043702948A5041831885 @default.
- W2043702948 hasAuthorship W2043702948A5042681217 @default.
- W2043702948 hasAuthorship W2043702948A5061505558 @default.
- W2043702948 hasAuthorship W2043702948A5074938996 @default.
- W2043702948 hasConcept C116569031 @default.
- W2043702948 hasConcept C145148216 @default.
- W2043702948 hasConcept C170493617 @default.
- W2043702948 hasConcept C178790620 @default.