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- W2043705701 abstract "<h2>Abstract</h2><h3>Objective</h3> The purpose of this study was to investigate the ovarian protective effects of resveratrol in rats exposed to total body irradiation. <h3>Design</h3> Experimental study. <h3>Settings</h3> University hospital. <h3>Participants and Interventions</h3> Thirty female rats were randomized into four groups: (1) control group (n = 7); (2) low-dose (10 mg/kg) resveratrol group (n = 8); (3) high-dose (100 mg/kg) resveratrol group (n =7); and (4) sham irradiation group (n = 8). The drugs were administered intraperitoneally as single doses, and the rats were exposed to total body radiation 24 h after the treatment. The animals were sacrificed the following day, and their ovaries were excised for histopathological and biochemical analysis. <h3>Main Outcome Measures</h3> The ovarian follicle counts were calculated, and irradiation-dependent ovarian damage and tissue levels of antioxidant enzymes were evaluated. <h3>Results</h3> Group 2 and Group 3 showed significantly higher numbers of total follicle counts compared with Group 1 (<i>P</i> < 0.01). The low-dose resveratrol treatment was associated with significantly higher numbers of primary follicles than the high-dose group. The tissue activities of glutathione peroxidase (GsH-Px) and catalase (CAT) were significantly elevated in the resveratrol-treated animals. Evaluation of ovarian histology revealed no remarkable changes in fibrosis and leucocyte infiltration among the resveratrol-treated and control rats; however, vascularity was significantly reduced in the high-dose group (<i>P</i> = 0.014). <h3>Conclusion</h3> Resveratrol attenuated irradiation-dependent ovarian damage, suggesting that this natural antioxidant is effective in reducing the follicle loss induced by ionizing radiation." @default.
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- W2043705701 date "2012-08-01" @default.
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- W2043705701 title "Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats" @default.
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- W2043705701 doi "https://doi.org/10.1016/j.jpag.2012.04.001" @default.
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