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• W2043713099 abstract "Drosophila Numb is a membrane associated protein of 557 amino acids (aa) that localizes asymmetrically into a cortical crescent in mitotic neural precursor cells and segregates into one of the daughter cells, where it is required for correct cell fate specification. We demonstrate here that asymmetric localization but not membrane localization of Numb in Drosophila embryos is inhibited by latrunculin A, an inhibitor of actin assembly. We also show that deletion of either the first 41 aa or aa 41–118 of Numb eliminates both localization to the cell membrane and asymmetric localization during mitosis, whereas C-terminal deletions or deletions of central portions of Numb do not affect its subcellular localization. Fusion of the first 76 or the first 119 aa of Numb to β-galactosidase results in a fusion protein that localizes to the cell membrane, but fails to localize asymmetrically during mitosis. In contrast, a fusion protein containing the first 227 aa of Numb and β-galactosidase localizes asymmetrically during mitosis and segregates into the same daughter cell as the endogenous Numb protein, demonstrating that the first 227 aa of the Numb protein are sufficient for asymmetric localization." @default.
• W2043713099 created "2016-06-24" @default.
• W2043713099 creator A5008803187 @default.
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• W2043713099 date "1997-11-25" @default.
• W2043713099 modified "2023-09-27" @default.
• W2043713099 title "The N terminus of the <i>Drosophila</i> Numb protein directs membrane association and actin-dependent asymmetric localization" @default.
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• W2043713099 doi "https://doi.org/10.1073/pnas.94.24.13005" @default.
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