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- W2043742160 abstract "This research update summarizes thirty years of studies on genetic influences on responses to the acute or chronic administration of nicotine. Early studies established that various inbred mice are differentially sensitive to the effects of the drug. Classical genetic analyses confirmed that nicotine effects on locomotion, body temperature and seizures are heritable. A significant inverse correlation between the locomotor and hypothermic effects and the density of nicotine binding sites suggested that differential expression α4β2-neuronal nicotinic acetylcholine receptor (nAChR) mediated some of this genetic variability. Subsequent studies with α4 and β2 nAChR null (decreased sensitivity) and gain of function mutants (increased sensitivity) supports the role of the α4β2*nAChR subtype. However, null mutant mice still respond to nicotine, indicating that other nAChR subtypes also mediate these responses. Mice differing in initial sensitivity to nicotine also differ in tolerance development following chronic treatment: those mice that are initially more sensitive to nicotine develop tolerance at lower treatment doses than less sensitive mice, indicating that tolerance is an adaptive response to the effects of nicotine. In contrast, the sensitivity of mice to pre-pulse inhibition of acoustic startle response is correlated with the expression of α7-nAChR. While genetic variability in nAChR expression and function is an important factor contributing to differences in response to nicotine, the observations that altered activity of opioid, glutamate, and cannabinoid receptors among others also change nicotine sensitivity reinforces the proposal that the genetics of nicotine response is more complex than differences in nAChRs." @default.
- W2043742160 created "2016-06-24" @default.
- W2043742160 creator A5080448364 @default.
- W2043742160 date "2013-10-01" @default.
- W2043742160 modified "2023-10-16" @default.
- W2043742160 title "Genetic matters: Thirty years of progress using mouse models in nicotinic research" @default.
- W2043742160 cites W1556409059 @default.
- W2043742160 cites W1615624892 @default.
- W2043742160 cites W1675823061 @default.
- W2043742160 cites W1896132173 @default.
- W2043742160 cites W1900806927 @default.
- W2043742160 cites W1963749323 @default.
- W2043742160 cites W1964755594 @default.
- W2043742160 cites W1966166712 @default.
- W2043742160 cites W1967226069 @default.
- W2043742160 cites W1967537545 @default.
- W2043742160 cites W1973295491 @default.
- W2043742160 cites W1973843705 @default.
- W2043742160 cites W1976458982 @default.
- W2043742160 cites W1981386943 @default.
- W2043742160 cites W1981844901 @default.
- W2043742160 cites W1985349781 @default.
- W2043742160 cites W1986325356 @default.
- W2043742160 cites W1986445622 @default.
- W2043742160 cites W1989449868 @default.
- W2043742160 cites W1995971676 @default.
- W2043742160 cites W1996157865 @default.
- W2043742160 cites W1996499810 @default.
- W2043742160 cites W1996662707 @default.
- W2043742160 cites W1997942208 @default.
- W2043742160 cites W2000584367 @default.
- W2043742160 cites W2003630255 @default.
- W2043742160 cites W2008410194 @default.
- W2043742160 cites W2008995782 @default.
- W2043742160 cites W2009331519 @default.
- W2043742160 cites W2009384374 @default.
- W2043742160 cites W2011914109 @default.
- W2043742160 cites W2016401719 @default.
- W2043742160 cites W2016885417 @default.
- W2043742160 cites W2024566705 @default.
- W2043742160 cites W2024916359 @default.
- W2043742160 cites W2028219374 @default.
- W2043742160 cites W2030157411 @default.
- W2043742160 cites W2032048698 @default.
- W2043742160 cites W2033865162 @default.
- W2043742160 cites W2034053561 @default.
- W2043742160 cites W2034434521 @default.
- W2043742160 cites W2037998605 @default.
- W2043742160 cites W2039224666 @default.
- W2043742160 cites W2040422782 @default.
- W2043742160 cites W2043259970 @default.
- W2043742160 cites W2044893269 @default.
- W2043742160 cites W2047877800 @default.
- W2043742160 cites W2048346500 @default.
- W2043742160 cites W2052869591 @default.
- W2043742160 cites W2057534176 @default.
- W2043742160 cites W2064794178 @default.
- W2043742160 cites W2065585470 @default.
- W2043742160 cites W2065671645 @default.
- W2043742160 cites W2069793642 @default.
- W2043742160 cites W2072052138 @default.
- W2043742160 cites W2076679093 @default.
- W2043742160 cites W2083220863 @default.
- W2043742160 cites W2085734568 @default.
- W2043742160 cites W2085742103 @default.
- W2043742160 cites W2091328294 @default.
- W2043742160 cites W2091374932 @default.
- W2043742160 cites W2092348373 @default.
- W2043742160 cites W2092364608 @default.
- W2043742160 cites W2100270845 @default.
- W2043742160 cites W2102621654 @default.
- W2043742160 cites W2111761092 @default.
- W2043742160 cites W2113452300 @default.
- W2043742160 cites W2117240999 @default.
- W2043742160 cites W2133971381 @default.
- W2043742160 cites W2135470793 @default.
- W2043742160 cites W2142268301 @default.
- W2043742160 cites W2142606268 @default.
- W2043742160 cites W2143989432 @default.
- W2043742160 cites W2146710322 @default.
- W2043742160 cites W2146809944 @default.
- W2043742160 cites W2147835957 @default.
- W2043742160 cites W2148168931 @default.
- W2043742160 cites W2150116538 @default.
- W2043742160 cites W2160714071 @default.
- W2043742160 cites W2161491285 @default.
- W2043742160 cites W2167841150 @default.
- W2043742160 cites W2284817657 @default.
- W2043742160 cites W2332441838 @default.
- W2043742160 cites W2337946333 @default.
- W2043742160 cites W4296759793 @default.
- W2043742160 cites W4320577279 @default.
- W2043742160 cites W2066681455 @default.
- W2043742160 doi "https://doi.org/10.1016/j.bcp.2013.05.021" @default.
- W2043742160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329927" @default.
- W2043742160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23747348" @default.
- W2043742160 hasPublicationYear "2013" @default.
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