FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043758951> ?p ?o ?g. }

• W2043758951 abstract "The major antigen-adapted immune response protecting a vertebrate against virus infection is that mediated by CTLs (cytotoxic T-lymphocytes). CTLs destroy virus-infected cells, thereby containing the infection. They are activated by recognition of peptide antigens or epitopes, presented to them in the context of MHC I proteins. These epitopes are derived from proteolytic degradation of endogenously synthesized proteins, which is mediated by the proteasome. Augmentation of epitope presentation by MHC I is thought to be effected by the immunoproteasome, induced in response to IFN-γ (interferon-γ) in some cells, and constitutively expressed in others. In this issue of the Biochemical Journal, Remoli and colleagues describe the manipulation of the immunoproteasome by the Tat (transcriptional activation) protein of HIV. The authors show that Tat deregulates the balance of the three proteins, LMP2 (low-molecular-mass polypeptide 2), LMP7 and MECL1 (multicatalytic endopeptidase complex-like 1), which distinguish the immunoproteasome from the proteasome, and they provide a molecular explanation. Intracellular Tat sequesters IRF-1 (interferon-regulatory factor-1) from its cognate promoter element, where normally it associates with STAT1 (signal transducer and activator of transcription 1) to activate basal transcription of the LMP2 gene. LMP2 expression is inhibited as a consequence, skewing the stoichiometry of the immunoproteasome and changing its enzymatic activity. These findings provide a molecular account of an immunomodulatory activity of HIV: changing the peptide antigen profile of cells expressing or exposed to Tat. They may also provide an avenue for manipulating vaccine efficacy and specificity with Tat-based adjuvants." @default.
• W2043758951 created "2016-06-24" @default.
• W2043758951 creator A5057925452 @default.
• W2043758951 creator A5084023575 @default.
• W2043758951 date "2006-05-15" @default.
• W2043758951 modified "2023-09-24" @default.
• W2043758951 title "HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity" @default.
• W2043758951 cites W1605749243 @default.
• W2043758951 cites W1967495326 @default.
• W2043758951 cites W1980532602 @default.
• W2043758951 cites W2007063498 @default.
• W2043758951 cites W2013513564 @default.
• W2043758951 cites W2016421479 @default.
• W2043758951 cites W2061171056 @default.
• W2043758951 cites W2078326860 @default.
• W2043758951 cites W2085384499 @default.
• W2043758951 cites W2110561490 @default.
• W2043758951 cites W2133707868 @default.
• W2043758951 cites W2134992605 @default.
• W2043758951 cites W2139405922 @default.
• W2043758951 doi "https://doi.org/10.1042/bj20060497" @default.
• W2043758951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462708" @default.
• W2043758951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16703666" @default.
• W2043758951 hasPublicationYear "2006" @default.
• W2043758951 type Work @default.
• W2043758951 sameAs 2043758951 @default.
• W2043758951 citedByCount "7" @default.
• W2043758951 countsByYear W20437589512012 @default.
• W2043758951 countsByYear W20437589512013 @default.
• W2043758951 countsByYear W20437589512016 @default.
• W2043758951 countsByYear W20437589512017 @default.
• W2043758951 countsByYear W20437589512021 @default.
• W2043758951 crossrefType "journal-article" @default.
• W2043758951 hasAuthorship W2043758951A5057925452 @default.
• W2043758951 hasAuthorship W2043758951A5084023575 @default.
• W2043758951 hasBestOaLocation W20437589512 @default.
• W2043758951 hasConcept C104317684 @default.
• W2043758951 hasConcept C108249834 @default.
• W2043758951 hasConcept C138885662 @default.
• W2043758951 hasConcept C147483822 @default.
• W2043758951 hasConcept C153911025 @default.
• W2043758951 hasConcept C154317977 @default.
• W2043758951 hasConcept C159047783 @default.
• W2043758951 hasConcept C170627219 @default.
• W2043758951 hasConcept C171958077 @default.
• W2043758951 hasConcept C179926584 @default.
• W2043758951 hasConcept C195616568 @default.
• W2043758951 hasConcept C202751555 @default.
• W2043758951 hasConcept C203014093 @default.
• W2043758951 hasConcept C207936829 @default.
• W2043758951 hasConcept C27740335 @default.
• W2043758951 hasConcept C2776178377 @default.
• W2043758951 hasConcept C2778923194 @default.
• W2043758951 hasConcept C41895202 @default.
• W2043758951 hasConcept C55493867 @default.
• W2043758951 hasConcept C62478195 @default.
• W2043758951 hasConcept C83464605 @default.
• W2043758951 hasConcept C86339819 @default.
• W2043758951 hasConcept C86803240 @default.
• W2043758951 hasConcept C8891405 @default.
• W2043758951 hasConcept C95444343 @default.
• W2043758951 hasConceptScore W2043758951C104317684 @default.
• W2043758951 hasConceptScore W2043758951C108249834 @default.
• W2043758951 hasConceptScore W2043758951C138885662 @default.
• W2043758951 hasConceptScore W2043758951C147483822 @default.
• W2043758951 hasConceptScore W2043758951C153911025 @default.
• W2043758951 hasConceptScore W2043758951C154317977 @default.
• W2043758951 hasConceptScore W2043758951C159047783 @default.
• W2043758951 hasConceptScore W2043758951C170627219 @default.
• W2043758951 hasConceptScore W2043758951C171958077 @default.
• W2043758951 hasConceptScore W2043758951C179926584 @default.
• W2043758951 hasConceptScore W2043758951C195616568 @default.
• W2043758951 hasConceptScore W2043758951C202751555 @default.
• W2043758951 hasConceptScore W2043758951C203014093 @default.
• W2043758951 hasConceptScore W2043758951C207936829 @default.
• W2043758951 hasConceptScore W2043758951C27740335 @default.
• W2043758951 hasConceptScore W2043758951C2776178377 @default.
• W2043758951 hasConceptScore W2043758951C2778923194 @default.
• W2043758951 hasConceptScore W2043758951C41895202 @default.
• W2043758951 hasConceptScore W2043758951C55493867 @default.
• W2043758951 hasConceptScore W2043758951C62478195 @default.
• W2043758951 hasConceptScore W2043758951C83464605 @default.
• W2043758951 hasConceptScore W2043758951C86339819 @default.
• W2043758951 hasConceptScore W2043758951C86803240 @default.
• W2043758951 hasConceptScore W2043758951C8891405 @default.
• W2043758951 hasConceptScore W2043758951C95444343 @default.
• W2043758951 hasIssue "2" @default.
• W2043758951 hasLocation W20437589511 @default.
• W2043758951 hasLocation W20437589512 @default.
• W2043758951 hasLocation W20437589513 @default.
• W2043758951 hasLocation W20437589514 @default.
• W2043758951 hasOpenAccess W2043758951 @default.
• W2043758951 hasPrimaryLocation W20437589511 @default.
• W2043758951 hasRelatedWork W1543322656 @default.
• W2043758951 hasRelatedWork W1700891670 @default.
• W2043758951 hasRelatedWork W1965588035 @default.
• W2043758951 hasRelatedWork W1971601964 @default.
• W2043758951 hasRelatedWork W1977889843 @default.
• W2043758951 hasRelatedWork W1984678830 @default.
• W2043758951 hasRelatedWork W2037612991 @default.

• next