FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043765720> ?p ?o ?g. }

• W2043765720 endingPage "462" @default.
• W2043765720 startingPage "450" @default.
• W2043765720 abstract "The biophysical properties and distribution of voltage-dependent, Ca2+ -modulated K+ (BKCa) currents among subpopulations of acutely dissociated DiI-labeled cutaneous sensory neurons from the adult rat were characterized with whole-cell patch-clamp techniques. BKCa currents were isolated from total K+ current with iberiotoxin, charybdotoxin or paxilline. There was considerable variability in biophysical properties of BKCa currents. There was also variability in the distribution of BKCa current among subpopulations of cutaneous dorsal root ganglia (DRG) neurons. While present in each of the subpopulations defined by cell body size, IB4 binding or capsaicin sensitivity, BKCa current was present in the vast majority (> 90%) of small-diameter IB4+ neurons, but was present in only a minority of neurons in subpopulations defined by other criteria (i.e. small-diameter IB4−). Current-clamp analysis indicated that in IB4+ neurons, BKCa currents contribute to the repolarization of the action potential and adaptation in response to sustained membrane depolarization, while playing little role in the determination of action potential threshold. Reverse transcriptase-polymerase chain reaction analysis of mRNA collected from whole DRG revealed the presence of multiple splice variants of the BKCa channel α-subunit, rslo and all four of the accessory β-subunits, suggesting that heterogeneity in the biophysical and pharmacological properties of BKCa current in cutaneous neurons reflects, at least in part, the differential distribution of splice variants and/or β-subunits. Because even a small decrease in BKCa current appears to have a dramatic influence on excitability, modulation of this current may contribute to sensitization of nociceptive afferents observed following tissue injury." @default.
• W2043765720 created "2016-06-24" @default.
• W2043765720 creator A5007205508 @default.
• W2043765720 creator A5009507330 @default.
• W2043765720 creator A5050639330 @default.
• W2043765720 creator A5067391726 @default.
• W2043765720 date "2010-02-01" @default.
• W2043765720 modified "2023-10-15" @default.
• W2043765720 title "BK_Cacurrents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons" @default.
• W2043765720 cites W1511198581 @default.
• W2043765720 cites W1530607424 @default.
• W2043765720 cites W1540607329 @default.
• W2043765720 cites W1555733423 @default.
• W2043765720 cites W1587611015 @default.
• W2043765720 cites W1667367966 @default.
• W2043765720 cites W1808292284 @default.
• W2043765720 cites W1815961026 @default.
• W2043765720 cites W1831695691 @default.
• W2043765720 cites W1886320289 @default.
• W2043765720 cites W1967619361 @default.
• W2043765720 cites W1968775375 @default.
• W2043765720 cites W1981669433 @default.
• W2043765720 cites W1982607515 @default.
• W2043765720 cites W1984491481 @default.
• W2043765720 cites W1991624086 @default.
• W2043765720 cites W1993563590 @default.
• W2043765720 cites W1995971403 @default.
• W2043765720 cites W2003404396 @default.
• W2043765720 cites W2006356077 @default.
• W2043765720 cites W2008465842 @default.
• W2043765720 cites W2010383551 @default.
• W2043765720 cites W2010938411 @default.
• W2043765720 cites W2016835465 @default.
• W2043765720 cites W2017515163 @default.
• W2043765720 cites W2024794798 @default.
• W2043765720 cites W2025408495 @default.
• W2043765720 cites W203575579 @default.
• W2043765720 cites W2038621068 @default.
• W2043765720 cites W2039303620 @default.
• W2043765720 cites W2039517962 @default.
• W2043765720 cites W2044382647 @default.
• W2043765720 cites W2047985837 @default.
• W2043765720 cites W2050725524 @default.
• W2043765720 cites W2063845237 @default.
• W2043765720 cites W2063983467 @default.
• W2043765720 cites W2073346073 @default.
• W2043765720 cites W2081370552 @default.
• W2043765720 cites W2083855520 @default.
• W2043765720 cites W2085169889 @default.
• W2043765720 cites W2085534162 @default.
• W2043765720 cites W2089157424 @default.
• W2043765720 cites W2091352000 @default.
• W2043765720 cites W2091685020 @default.
• W2043765720 cites W2093404236 @default.
• W2043765720 cites W2098676092 @default.
• W2043765720 cites W2102693353 @default.
• W2043765720 cites W2117266710 @default.
• W2043765720 cites W2122203983 @default.
• W2043765720 cites W2131712556 @default.
• W2043765720 cites W2132882998 @default.
• W2043765720 cites W2135531905 @default.
• W2043765720 cites W2141832664 @default.
• W2043765720 cites W2147948348 @default.
• W2043765720 cites W2278016499 @default.
• W2043765720 cites W2331570632 @default.
• W2043765720 cites W2395513110 @default.
• W2043765720 cites W2416337138 @default.
• W2043765720 cites W4244608670 @default.
• W2043765720 cites W4323874226 @default.
• W2043765720 doi "https://doi.org/10.1111/j.1460-9568.2009.07060.x" @default.
• W2043765720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843514" @default.
• W2043765720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20105244" @default.
• W2043765720 hasPublicationYear "2010" @default.
• W2043765720 type Work @default.
• W2043765720 sameAs 2043765720 @default.
• W2043765720 citedByCount "54" @default.
• W2043765720 countsByYear W20437657202012 @default.
• W2043765720 countsByYear W20437657202013 @default.
• W2043765720 countsByYear W20437657202014 @default.
• W2043765720 countsByYear W20437657202015 @default.
• W2043765720 countsByYear W20437657202016 @default.
• W2043765720 countsByYear W20437657202017 @default.
• W2043765720 countsByYear W20437657202018 @default.
• W2043765720 countsByYear W20437657202019 @default.
• W2043765720 countsByYear W20437657202020 @default.
• W2043765720 countsByYear W20437657202021 @default.
• W2043765720 countsByYear W20437657202022 @default.
• W2043765720 countsByYear W20437657202023 @default.
• W2043765720 crossrefType "journal-article" @default.
• W2043765720 hasAuthorship W2043765720A5007205508 @default.
• W2043765720 hasAuthorship W2043765720A5009507330 @default.
• W2043765720 hasAuthorship W2043765720A5050639330 @default.
• W2043765720 hasAuthorship W2043765720A5067391726 @default.
• W2043765720 hasBestOaLocation W20437657202 @default.
• W2043765720 hasConcept C12554922 @default.
• W2043765720 hasConcept C147944092 @default.
• W2043765720 hasConcept C15490471 @default.
• W2043765720 hasConcept C169760540 @default.

• next