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- W2043774554 abstract "Published reports of “adenoacanthoma” of the endometrium have usually included both those cases in which the squamous elements are histologically benign and those in which they are histologically malignant. In the present report, cases with the former appearance have been classified as adenoacanthoma (or adenocarcinoma with squamous metaplasia), but tumors with malignant-appearing squamous cells have been grouped separately as mixed adenosquamous carcinoma. Of 148 consecutive cases reviewed, 71 (48.0%) were adenocarcinomas (AC), 44 (29.7%) were adenoacanthomas (AA), 26 (17.6%) were mixed carcinomas (MC), and 7 (4.7%) were clear cell carcinomas. Clinically, there were no major differences among patients with the three predominant tumor types, but there was a tendency toward later menopause and lower gravidity among those women whose tumors contained squamous elements (AA and MC). Despite similar treatment regimens and clinical staging, actuarial 5-year survival was 56.3% for AC, 82.9% for AA, and 35.3% for MC. Patients with MC also had a higher incidence of persistent tumor after irradiation, deeper penetration of tumor in hysterectomy specimens, and a tendency to earlier recurrences. When the MC pateints were compared with only women with poorly differentiated AC (since the glandular elements were almost always poorly differentiated in MC tumors), these two groups were quite similar in most parameters, including 5-year survival. Similar comparisons between AA and well-differentiated AC reveal that, despite similarities in all other respects, the 5-year survival remains significantly higher in AA (82.9% vs. 60.6%). Thus, it appears that the poorly differentiated (i.e., histologically malignant) squamous elements in MC are a function of poorly differentiated glandular elements and may not significantly worsen an already unfavorable prognosis. The ability of a well-differentiated carcinoma to form histologically benign squamous elements, on the other hand, seems to improve a prognosis which is already relatively favorable. Tumors formerly indiscriminately classified as adenoacanthoma should now be separated into two distinct groups, and these relationships should be investigated further." @default.
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- W2043774554 date "1972-11-01" @default.
- W2043774554 modified "2023-09-27" @default.
- W2043774554 title "Adenoacanthoma and mixed adenosquamous carcinoma of the endometrium.A clinicopathologic study" @default.
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- W2043774554 doi "https://doi.org/10.1002/1097-0142(197211)30:5<1307::aid-cncr2820300524>3.0.co;2-r" @default.
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