FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043792125> ?p ?o ?g. }

• W2043792125 endingPage "996" @default.
• W2043792125 startingPage "989" @default.
• W2043792125 abstract "Gonadotropins play a crucial role in ovarian homeostasis and fertilization through the activation of the cAMP cascade. However, gonadotropin hyper-stimulation may be associated with higher risk for ovarian cancer development. It has been suggested, that high gonadotropin levels in peritoneal and ovarian cystic fluids of patients suffering from benign ovarian cysts, may lead to malignancy. Moreover, we have recently discovered that gonadotropin stimulation can activate the MAPK cascade in target cells. Using DNA microarray technology and RNA from human granulosa cells, we discovered that stimulation with saturating doses of gonadotropins dramatically elevates activity of genes coding for epiregulin and amphiregulin. These gene products can bind and activate the EGF receptor and ERBB4, which are associated with the development of various cancers such as ovarian, breast endometrial and other non-gynecological malignancies. Gonadotropin receptors are expressed not only in the gonads, but also in non-gonadal tissues and in cancer cells. The discovery that gonadotropins activate certain mitogenic signal transduction pathways, may serve as a guide for novel anti-cancer therapy by (1) specific interference at the receptor level to block the gonadotropic response, or arresting the receptor expression and (2) blocking downstream mitogenic signals generated by these hormones, like attenuation of the expression of epiregulin and amphiregulin that belong to the EGF family, using anti-sense and/or SiRNA techniques targeted to suppress their expression. Moreover, since amphiregulin and epiregulin act as mediators of luteinizing hormone (LH) action in the mammalian ovulatory follicles, regulation of the expression of these factors may open new possibilities in treatment of ovarian malfunction implicated with ovarian hyper-stimulation." @default.
• W2043792125 created "2016-06-24" @default.
• W2043792125 creator A5002130819 @default.
• W2043792125 creator A5056053145 @default.
• W2043792125 creator A5065443593 @default.
• W2043792125 creator A5073898076 @default.
• W2043792125 creator A5082577937 @default.
• W2043792125 creator A5086856217 @default.
• W2043792125 date "2004-09-01" @default.
• W2043792125 modified "2023-09-27" @default.
• W2043792125 title "Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis" @default.
• W2043792125 cites W111758181 @default.
• W2043792125 cites W1599163395 @default.
• W2043792125 cites W1967661601 @default.
• W2043792125 cites W1973393731 @default.
• W2043792125 cites W1978362571 @default.
• W2043792125 cites W1980556848 @default.
• W2043792125 cites W1982837090 @default.
• W2043792125 cites W1983200944 @default.
• W2043792125 cites W1983652526 @default.
• W2043792125 cites W1985492640 @default.
• W2043792125 cites W1988808169 @default.
• W2043792125 cites W1996038131 @default.
• W2043792125 cites W1999178805 @default.
• W2043792125 cites W2002773890 @default.
• W2043792125 cites W2002885378 @default.
• W2043792125 cites W2005140082 @default.
• W2043792125 cites W2009224756 @default.
• W2043792125 cites W2012322739 @default.
• W2043792125 cites W2013475581 @default.
• W2043792125 cites W2014958824 @default.
• W2043792125 cites W2015328614 @default.
• W2043792125 cites W2015524046 @default.
• W2043792125 cites W2022013947 @default.
• W2043792125 cites W2022779155 @default.
• W2043792125 cites W2022839567 @default.
• W2043792125 cites W2025029381 @default.
• W2043792125 cites W2025054017 @default.
• W2043792125 cites W2029515001 @default.
• W2043792125 cites W2030040451 @default.
• W2043792125 cites W2035861202 @default.
• W2043792125 cites W2042977552 @default.
• W2043792125 cites W2046535196 @default.
• W2043792125 cites W2047994983 @default.
• W2043792125 cites W2048466881 @default.
• W2043792125 cites W2048655019 @default.
• W2043792125 cites W2048971528 @default.
• W2043792125 cites W2063081210 @default.
• W2043792125 cites W2065779723 @default.
• W2043792125 cites W2069653953 @default.
• W2043792125 cites W2081104479 @default.
• W2043792125 cites W2083030380 @default.
• W2043792125 cites W2084172300 @default.
• W2043792125 cites W2085867052 @default.
• W2043792125 cites W2087666626 @default.
• W2043792125 cites W2103159925 @default.
• W2043792125 cites W2122341014 @default.
• W2043792125 cites W2123161822 @default.
• W2043792125 cites W2123579537 @default.
• W2043792125 cites W2145837099 @default.
• W2043792125 cites W2150370884 @default.
• W2043792125 cites W2168275924 @default.
• W2043792125 cites W2281191439 @default.
• W2043792125 cites W2315888143 @default.
• W2043792125 cites W2340830559 @default.
• W2043792125 cites W2415070932 @default.
• W2043792125 cites W3023202846 @default.
• W2043792125 cites W58209284 @default.
• W2043792125 cites W65620772 @default.
• W2043792125 doi "https://doi.org/10.1016/j.bcp.2004.05.027" @default.
• W2043792125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15313392" @default.
• W2043792125 hasPublicationYear "2004" @default.
• W2043792125 type Work @default.
• W2043792125 sameAs 2043792125 @default.
• W2043792125 citedByCount "21" @default.
• W2043792125 countsByYear W20437921252012 @default.
• W2043792125 countsByYear W20437921252013 @default.
• W2043792125 countsByYear W20437921252014 @default.
• W2043792125 countsByYear W20437921252015 @default.
• W2043792125 countsByYear W20437921252016 @default.
• W2043792125 countsByYear W20437921252017 @default.
• W2043792125 countsByYear W20437921252019 @default.
• W2043792125 countsByYear W20437921252021 @default.
• W2043792125 crossrefType "journal-article" @default.
• W2043792125 hasAuthorship W2043792125A5002130819 @default.
• W2043792125 hasAuthorship W2043792125A5056053145 @default.
• W2043792125 hasAuthorship W2043792125A5065443593 @default.
• W2043792125 hasAuthorship W2043792125A5073898076 @default.
• W2043792125 hasAuthorship W2043792125A5082577937 @default.
• W2043792125 hasAuthorship W2043792125A5086856217 @default.
• W2043792125 hasConcept C121608353 @default.
• W2043792125 hasConcept C126322002 @default.
• W2043792125 hasConcept C134018914 @default.
• W2043792125 hasConcept C170493617 @default.
• W2043792125 hasConcept C2776362946 @default.
• W2043792125 hasConcept C2777968868 @default.
• W2043792125 hasConcept C2778782382 @default.
• W2043792125 hasConcept C2780427987 @default.

• next